端粒保护蛋白TRF2在肿瘤发生和治疗中作用机制的研究进展

Research progress in the mechanism of telomeric shelterin component TRF2 in tumorigenesis and tumor treatment

端粒重复序列结合因子2(telomeric-repeat binding factor 2,TRF2)是一种重要的端粒保护蛋白,与端粒保护蛋白1(protection of telomeres 1,POT1)、端粒重复序列结合因子1(telomeric-repeat binding factor 1,TRF1)、相互作用核蛋白2(TRF1-interacting nuclear protein 2,TIN2)、阻滞活化蛋白1(repressor activator protein 1,Rap1)以及TPP1,5个核心蛋白通过一系列相互作用共同形成端粒保护蛋白复合体(shelterin)以维持端粒结构和功能的稳定性和完整性。越来越多的研究显示TRF2在多种肿瘤中异常表达并与肿瘤的发生,肿瘤细胞的耐药以及肿瘤血管的生成密切相关。因此,本文就TFR2的结构与生理功能,以及其在肿瘤发生,发展与治疗中的作用研究进展进行综述,以期为肿瘤的预防和治疗提供新的思路。

Telomeric-repeat binding factor 2 {TRF2） as an important telomere binding protein, protects telomere ends and maintains the structural and functional stability and integrity of telomeres by interacting with five other essential core proteins （POT1, TRF1, TIN2, RAP1, and TPP1） to form a complex called shelterin. An increasing number of studies have discovered the abnormal expression of TRF2 in many tumors and that TRF2 is closely related to tumor occurrence, drug resistance, and tumor angiogenesis. Here, we re- view the latest research findings on the structure and function of TRF2, as well as the role of TRF2 in the occurrence, development, and treatment of tumors. We hope to provide novel perspectives for the prevention and treatment of tumors.