甘肃兰州地区妊娠期血清甲状腺激素参考值范围的研究

Study on reference value range of serum thyroid hormone in pregnancy in Lanzhou,Gansu Province

目的研究甘肃兰州地区妇女妊娠各期血清甲状腺激素医学参考值范围。方法收集2015年10月至2016年6月在兰州大学第二医院妇产科门诊产检的单胎妊娠健康孕妇562例,其中孕早期(T1)238例,孕中期(T2)192例,孕晚期(T3)132例;选取52例非妊娠健康育龄期妇女作为对照组。用Siemens ADVIA Centaur XP检测仪化学发光法检测甲状腺激素(thyroid-stimulating hormone,TSH)、游离甲状腺素(free thyroxine,FT_4)和游离三碘甲状腺原氨酸(free triiodothyronine,FT_3),并对结果进行统计分析,建立该地区妊娠期甲状腺激素医学参考值范围。结果甘肃兰州地区妊娠期TSH参考值范围在孕早、中、晚期分别为0.05~5.58 mU/L、0.26~4.80 mU/L、0.21~5.11 mU/L;FT_4在孕早、中、晚期分别为10.73~19.15 pmol/L、10.26~18.06 pmol/L、9.94~16.35 pmol/L。TSH在孕早期最低,FT_4最高,妊娠各期参考范围有差异,孕期与非孕期参考范围存在差异。结论建立甘肃兰州地区妊娠期甲状腺激素参考值范围十分重要与必要。

Objective To study the reference value range of serum thyroid hormone in pregnancy in Lanzhou, Gansu. Methods 562 healthy pregnant women of single pregnancy from October 2015 to June 2016 in Obstetrics and Gynecology Clinic of Second Hospital of Lanzhou University were selected, in which 238 cases were in first trimester （T1）, 192 cases were in second trimester （T2） , and 132 cases were in third trimester （T3）. 52 cases of non -pregnant women of childbearing age were selected as control group. Detected thyroid - stimulating hormone （ TSH ） and free thyroxine （ FT4 ） and free triiodothyronine （ FT3 ） by Siemens ADVIA Centaur XP detector, and the results were statistically analyzed to establish the medical reference range of thyroid hormone during pregnancy in the area. Results TSH reference range during pregnancy in the first, second and third trimester of pregnancy were0.05 - 5.58 mU/L, 0.26 - 4.80mU/L, 0.21 - 5.11 mU/L; FT4were 10.73 - 19. 15 pmol/L, 10.26 - 18.06 pmol / L, 9. 94 - 16. 35pmol/L ,respectively. TSH was the lowest, FT4 the highest in early pregnancy, and the reference range was different in different pregnant periods. There was a difference in the reference range between pregnancy and non -pregnancy. Conclusion It is very important and necessary to build the reference ranges of thyroid hormones during pregnancy in Lanzhou, Gansu Province.