重复经颅磁刺激联合认知行为训练治疗注意力缺陷伴多动障碍儿童的疗效

Effect of repetitive transcranial magnetic stimulation combined with cognitive behavior training on children with attention deficit hyperactivity disorder

目的:观察重复经颅磁刺激(repetitive transcranial magnetic stimulation,r TMS)联合认知行为训练治疗注意力缺陷伴多动障碍(attention deficit hyperactivity disorder,ADHD)患儿的临床疗效。方法:60例ADHD患儿按随机数字表法分为对照组和实验组,每组30例。对照组常规采用认知行为治疗,实验组在采用认知行为训练基础上加用rTMS,治疗前后采用数字划消测试(Number Cancel Test,NCT)和Conners父母量表(Parents Symptom Questionnaire,PSQ)进行评估。结果:对照组治疗前后数字划消测试及Conners父母量表评分差异均有统计学意义(P<0.01),实验组治疗前后数字划消测试及Conners父母量表评分差异均有统计学意义(P<0.0 1)。实验组与对照组治疗后数字划消测试划在对数、划漏数和净分三项评分差异亦均有统计学意义(均P<0.01),在Conners父母量表评分中学习问题和多动指数两项评分差异亦均有统计学意义(均P<0.05)。结论:认知行为训练、r TMS联合认知行为训练治疗ADHD患者均有显著疗效。r TMS联合认知行为训练在治疗ADHD患者与单纯认知行为训练相比有疗效优势。

Objective： To observe the treatment effect of the repetitive transcranial magnetic stimulation （rTMS） combined with cognitive behavior training on attention deficit hyperactivity disorder （ADHD） in children Methods： Sixty patients with ADHD were randomly divided into an experimental group and a control group, 30 in each group. The experiment group was treated with rTMS combined with cognitive behavior training, while the control group with cognitive behavior training. Number Cancel Test （NCT） and Conners Parents Symptom Questionnaire （PSQ） were used to evaluate before and after the treatment. Results： Eight weeks after the treatment, the results of NCT and PSQ_were better than that before in both groups, the differences werestatistically significant （P〈0.01）. After the treatment, scores of NCT and PSQwere statistically different between the two groups （P〈0.05）. Conclusion： rTMS combined with cognitive behavior training has a significant effect on ADHD, which is a safe and efficient intervention for the ADHD children.