认知行为治疗对改善乳腺癌患者术后抑郁以及生活质量的Meta分析

A meta-analysis of cognitive behavioral therapy in improving postoperative depression and quality of life in patients with breast cancer

目的:通过Meta分析的方法评价认知行为治疗(cognitive behavioral therapy,CBT)对改善乳腺癌患者术后抑郁以及生活质量的效果。方法:手动检索Cochrane Library,EMBASE,Pub Med,Web of Science英文数据库以及中国生物医学文摘数据库(CBM)、维普数据库(VIP)、万方数据库及中国知网数据库(CNKI),纳入认知行为疗法改善术后抑郁以及生活质量的随机对照研究,评价结果包括焦虑自评量表(Self-Rating Anxiety Scale,SAS)评分,抑郁自评量表(Self-Rating Depression Scale,SDS)评分、生活质量核心问卷(Qualit y of Life-Core 30 Questionnaire,QLQ-C30)总分以及各个项目的评分进行Meta分析。结果:共纳入17篇文献,纳入患者1 645例,认知行为护理组832例,对照组813例。与对照组比较,行为认知疗法可以改善乳腺癌患者术后抑郁以及焦虑情绪评分,差异有统计学意义(P<0.05)。同时行为认知疗法可以降低患者术后QLQ-C30各个项目评分,差异有统计学意义(P<0.05)。结论:认知行为疗法可以改善乳腺癌患者术后抑郁以及焦虑情绪,改善患者生活质量。

Objective： To evaluate the effect of cognitive behavior therapy on depression and quality of life in patients with breast cancer through a meta-analysis. Methods： Medline, Cochrane library, EMBASE, PubMed, VIP, CBM, Chinese Wanfang database and CNKI database were manually searched. Any studies involving cognitive behavioral therapy and control group to improve depression after operation and life quality were picked. Self- Rating Anxiety Scale （SAS） score, Self-Rating Depression Scale （SDS） score and Quality of Life-Core 30 Questionnaire （QLQ-C30） score of each project were list as the main outcomes. Stata 12.0 was used for Meta-analysis. Results： A total of 17 articles were included in this study. Among them, there were 832 patients in the cognitive behavioral nursing group and 813 in the control group. Compared with the control group, the behavior cognitive therapy improved the postoperative depression and anxiety scores of breast carcinoma patients, and the differences between these two therapy methods was statistically significant （P〈0.05）. At the same time, cognitive behavior therapy improved the quality of life of patients after operation with statistically significant （P〈0.05）. Conclusion： Cognitive behavioral therapy can improve the quality of life of patients with breast cancer.