粒细胞-巨噬细胞集落刺激因子治疗肺泡蛋白沉积症1例

One case of granulocyte-macrophage colony stimulating factor therapy for alveolar protein deposition

收集1例肺泡蛋白沉积症(pulmonary alveolar proteinosis,PAP)患者临床资料并相关文献复习。患者因气短4个月,加重1个月入院,行纤维支气管镜活检。经过碘酸雪夫(Periodic acid-Schiff,PAS)染色阳性明确诊断为PAP,在经2次全肺灌洗治疗,病情反复后给予皮下注射粒细胞–巨噬细胞集落刺激因子,病情得到改善,提示对特发性PAP患者皮下注射粒细胞–巨噬细胞集落刺激因子是一种可行的治疗方法。

The clinical data of 1 patient with pulmonary alveolar proteinosis were collected and the related literatures were reviewed. Patient was hospitalized with air shortness of time for 4 months, 1-month exacerbation, and did transbronchial biopsy. After Periodic acid-Schiff staining positive, the patient was diagnosed as pulmonary alveolar protein deposition. After the whole lung lavage for 2 times, the patient was given subcutaneous injection of granulocyte-macrophage colony stimulating factor after the disease repeating; the condition of the state improved as well. It suggests that subcutaneous injection of granulocyte-macrophage colony stimulating factor in idiopathic PAP patients is a viable method.