探究胺碘酮治疗充血性心力衰竭合并室性心律失常的临床价值

Clinical effect of amiodarone in treatment of congestive heart failure complicated by ventricular arrhythmia

目的探讨分析充血性心力衰竭合并室性心律失常患者采取胺碘酮治疗方案的临床表现。方法将我院2012年4月至2016年10月的60例充血性心力衰竭合并室性心律失常患者随机分为两组,即对照组30例和实验组30例,对照组采取常规抗心衰治疗,而实验组采取常规抗心衰外加胺碘酮治疗策略,观察并分析充血性心力衰竭合并室性心律失常患者的临床表现和不良状况。结果实验组的临床效果优于对照组,实验组的临床有效率为96.67%,对照组的临床有效率为76.67%,两组的数据差别很大,差异具有统计学意义(P<0.05)。实验组的不良反应发生情况优于对照组,实验组的不良反应发生率为10.74%,对照组的不良反应发生率为9.67%,差异无统计学意义(P<0.05)。结论充血性心力衰竭合并室性心律失常患者采取胺碘酮治疗后,可以显著提高临床效果,改善患者的身体健康状况,无明显不良反应,有利于提高患者的生活质量,值得在临床推广。

Objective To investigate the clinical effect of amiodarone in the treatment of congestive heart failure complicated by ventricular arrhythmia. Methods A total of 60 patients with congestive heart failure complicated by ventricular arrhythmia who were treated in our hospital from April 2012 to October 2016 were enrolled and randomly divided into experimental group and control group, with 30 patients in each group. The patients in the control group were given conventional treatment for heart failure, and those in the experimental group were given amiodarone in addition to the conventional treatment for heart failure. Clinical manifestation and adverse events were observed for all patients. Results The experimental group had a significantly better clinical outcome and a significantly higher response rate than the control group （96.67% vs 76.67%, P〈0.05）. There was no significant difference in the incidence rate of adverse events between the experimental group and the control group （10.74% vs 9.67%, P〉0.05）. Conclusion In patients with congestive heart failure complicated by ventricular arrhythmia, amiodarone can significantly improve their clinical outcomes, health status, and quality of life with few adverse effects, and therefore, it holds promise for clinical application.