高迁移率族蛋白B1与肝脏疾病关系的研究进展

Advances in the study of the relationship between high mobility group box B1 protein and liver diseases

高迁移率族蛋白B1(HMGB1)是一种广泛存在于哺乳动物细胞内的损伤相关模式分子。作为一种晚期促炎因子,释放到细胞外的HMGB1可与其受体结合,在炎性损伤等疾病的发生发展中起重要作用,文章就HMGB1在药物性肝损伤、肝纤维化、肝衰竭、肝癌等肝脏疾病中的研究进展作一综述,为肝脏疾病的临床诊疗提供新的思路。

High mobility group box 1 （HMGB1） is a damage associated molecular pattern exists ubiquitously in the cells of mammals.As a late pro-inflammatory factor, extracellular HMGB1 combines with its receptors, and plays an important role in the development of inflammatory diseases and injuries.This paper reviews the research progress of HMGB1 in drug induced liver injury, hepatic fibrosis, liver failure, hepatic carcinoma, and provides new methods for clinical diagnosis and treatment of liver diseases.