中国海南百岁老人队列研究：研究设计及初步结果

China Hainan Centenarian Cohort Study： study design and preliminary results

目的 调查海南百岁老年人群的健康状况、功能状态、精神心理、卫生需求等其他长寿相关的流行病学特征及其主要影响因素，以探讨长寿及衰老的自然历程及相关机制。方法 中国海南百岁老人队列研究（CHCCS）是一项基于社区人群，具有问卷信息、身体测量、生物标本、临床影像等数据库和生物样本资料的全省百岁老人全样本的前瞻性队列研究。2014-2017年为基线调查，根据海南省民政部门提供的百岁老人户籍信息，对全省18市（县）百岁老人和5市（县）高龄对照老人进行入户调查，调查内容主要包括问卷访谈、体格检查和生物标本采集。计划每2年随访1次其患病与生存现状。结果 在海南省民政部门2014年提供的百岁老人名单中，1 473位百岁老人健在并可取得联系。截至2016年12月，其中的268人去世，203人拒访，1 002位百岁老人同意参加本研究。本文对海南百岁老人队列2014-2016年完成调查且资料完整的722例百岁老人的基线数据进行了初步分析，其平均年龄为（102.7±2.7）岁，女性占83.0%、丧偶占88.8%、汉族占84.5%、与家人同居者占87.8%、文盲占89.7%、农民占81.0%。结论 CHCCS将提供我国及亚洲最大样本的长寿人群的数据资料，并抢救性采集其珍稀的生物样本资源，为我国长寿、衰老及健康老龄化研究提供多学科交叉的技术平台和研究基地。

Objective To investigate the health status, functional ability, mental psychology, health care and other longevity-related characteristics of individuals aged ≥ 100 years as well as risk factors in Hainan province, China. Methods China Hainan Centenarian Cohort Study （CHCCS） is a community-based, prospective cohort study to establish multi-dimensional database consisting of questionnaire findings, anthropometric parameters and biological specimens as well as imaging features. With the household registration information provided by the Department of Civil Affairs of Hainan province, a baseline survey was conducted in centenarians in 18 counties in Hainan with the oldest old in 5 counties as controls between 2014 and 2017. The survey included face to face interview, physical examination and biological specimen collection. After the baseline survey, the participants of CHCCS were followed up at an interval of 2 years to collect the information about their living status, disease status or major death causes. Results According to the information provided by the Department of Civil Affairs of Hainan province in 2014, the survey found that 1 473 centenarians were still living. By December 2016, 1 002 of them had agreed to be surveyed. The average age of 722 centenarians with complete information in the baseline survey was （102.7±2.7） years, the majority of them were females （83.0%）, widows （88.8%）, in Han ethnic group （84.5%）, lived with family members （87.8%）, illiterates （89.7%） and farmers （81.0%）. Conclusion CHCCS has provided longevity-related information of the large longevity population and collected the valuable and rare biological specimens with great urgency to establish an interdisciplinary platform and base for longevity, senility and healthy aging research.