帕瑞昔布钠联合曲马多及舒芬太尼静脉镇痛泵多模式镇痛在腰椎手术后的应用效果

Application of Parecoxib Combined with Tramadol and Sufentanil Intravenous Analgesia Pump in Multimodal Analgesia after Lumbar Spine Surgery

目的观察帕瑞昔布钠联合曲马多及舒芬太尼静脉镇痛泵多模式镇痛在腰椎手术后的应用效果。方法将2015年5月—2017年5月180例在该院进行腰椎手术的患者随机分为3组,分别命名为A、B、C组,其中每组60例。诱导所有患者后,A组:术前30 min静注帕瑞昔布钠40 mg。B组:术前30 min静注帕瑞昔布钠40 mg,手术结束前30 min静脉推注曲马多100 mg。C组:无围手术期用药,3组患者术后均使用镇痛泵。手术后6、12、24 h,分别观察3组患者的疼痛视觉模拟评分(VAS)和镇静程度。结果其中A、B两组的镇静程度分别为高于C组(P<0.05),而A、B两组之间差异无统计学意义(P>0.05)。疼痛评分及不良反应C组显著高于A和B两组(P<0.05)。结论帕瑞昔布钠联合曲马多及舒芬太尼静脉镇痛泵多模式镇痛在腰椎手术后的应用效果良好。

Objective This paper tries to observe the effect of parecoxib combined with tramadol and sufentanil in tra -venous analgesia pump in multimodal analgesia after lumbar spine surgery. Methods 180 patients underwent lumbar spine surgery in this hospital from May 2015 to May 2017 were randomly divided into three groups： group A, B and C, with 60 cases in each group. After induct ion of all patients, group A： 30 minutes before the operation of intravenous in-ject ion of patients with parecoxib sodium 40 mg; group B： 30 minutes before surgery for patients with parecoxib 40 mg, 30 minutes before the end of surgery with intravenous tramadol 100 mg; Group C： no use of drugs preoperative and postoperative, all the patients were given analgesia pump. Visual analogue scale and sedation score were observed in three groups of patients after 6 h, 12 h and 24 h of operation. Results The sedation degree of group A and group B was higher that of group C（P〈0.05）. There was no significant difference between group A and group B. The VAS score of group C was significantly higher than that of group A and group B （P〈0.05）. Conclusion The application effect of parecoxib sodium combined with tramadol and sufentanil intravenous analgesia pump multimodal analgesia in lumbar surgery is good.