探析拉贝洛尔结合硫酸镁用于治疗重症妊娠高血压对分娩结局的影响效果

Effect of Labetalol Combined with Magnesium Sulfate for the Treatment of Severe Hypertension of Pregnancy on Delivery Outcome

目的探析拉贝洛尔联合硫酸镁治疗重症妊娠高血压的疗效。方法选取2014年8月—2017年2月该院经诊断确诊为重症妊娠高血压患者100例患者作为研究对象,经随机数字法均分为两组,即A组(给予硫酸镁治疗)与B组(给予拉贝洛尔联合硫酸镁治疗)。治疗后统计对比两组血压改善与母婴结局情况。结果治疗后B组血压[收缩压:(136.59±12.37)mmHg;舒张压:(95.61±10.21)mmHg]改善情况优于A组[收缩压:(148.46±12.85)mmHg;舒张压:(100.37±12.84)mmHg],差异有统计学意义(P<0.05)。两组母婴结局(A组:先兆子痫发生率18%、新生儿窒息发生率30%与妊娠终止26%;B组:先兆子痫发生率4%、新生儿窒息发生率6%与妊娠终止4%)对比差异有统计学意义(P<0.05);但两组产后出血率(A组6%与B组4%)比较差异无统计学意义(P>0.05)。结论重症妊娠高血压患者经拉贝洛尔与硫酸镁联合治疗的效果确切,不但可降低血压,还可使母婴结局得到改善。

Objective This paper tries to the curative effect of labetalol combined with magnesium sulfate for the treatment of severe hypertension of pregnancy. Methods 100 patients from August 2014 to February 2017 in the hospi-tal diagnosed with severe pregnancy induced hypertension were selected and randomly divided into two groups： group A （treating with magnesium sulfate） and group B （treating with combined magnesium sulfate and labetalol）. The efficacy and the maternal and neonatal outcomes of the two groups after treatment were compared. Results After treatment, the blood pressure [systolic blood pressure： （136.59±12.37）mmHg; diastolic blood pressure： （95.61±10.21）mmHg] in group B was better than that in group A of [systolic pressure： （148.46±12.85）mmHg; diastolic blood pressure： （100.37±12.84） mmHg], there was statistically significant difference（P〈0.05）. Two groups of maternal and infant outcomes（group A： Preeclampsia incidence rate was 18%, the incidence of neonatal asphyxia was 30% and pregnancy termination was 26%; group B： Preeclampsia incidence rate was 4%, the incidence of neonatal asphyxia was 6% and pregnancy termi-nation was 4%）, so there was statist ical difference between the two groups（P〈0.05）, but the two groups has no statist ical significance in the rate of postpartum hemorrhage （group A was 6%, group B was 4%）（P〉0.05）. Conclusion Labetalol combined with magnesium sulfate for the treatment of severe patients with hypertension is effective, not only can decline the blood pressure, but also can make the maternal and neonatal outcomes improved.