外周血相关参数对肝癌预后评估价值的研究进展

Research Progress of Peripheral Blood Relevant Parameters in the Evaluation of Prognosis of Hepatocellular Carcinoma

肝癌的发病率位居我国恶性肿瘤的第3位,居肿瘤死亡原因的第4位。研究显示炎症促进肝细胞肝癌的恶性生物学行为,并且和患者的预后相关。有研究发现了一些与患者预后相关的参数,如中性粒细胞(N)、淋巴细胞(L)、血小板(PLT)、C反应蛋白(CRP)、红细胞分布宽度(RDW)、中性粒细胞/淋巴细胞(NLR)、血小板/淋巴细胞(PLR)、C反应蛋白/白蛋白(CRP/Alb)。研究显示N的浸润与肝癌患者预后较差相关。CD4+CD25+Fox P3+调节T细胞数量增加可能导致肝癌患者生存时间减少。PLT与肝癌的发展、生长、侵袭和转移是相关的。CRP的升高与肝癌患者预后不良相关。RDW升高的患者生存率明显较差。NLR升高与肝癌术后的复发和预后有明显的相关性。升高的PLR与肝癌患者的生存率相关。CRP/Alb可能是肝癌患者独立的预后指标。上述指标目前缺乏统一的标准,具体机制尚不清楚。文章对外周血相关参数对肝癌预后评估价值的研究进展作一综述。

The morbidity of hepatocellular carcinoma （HCC） is in the third, the leading causes of death is in the fourth in China. Recently, it is indicated that inflammation can facilitate maligant biological behaviors of hepatocellular carcinoma and associated with the prognosis of patients with HCC. It has been found that associated with the prognosis of patients for clinical commom parameters. Such as, neutrophil, lymphocyte, platelet, C-reactive protein（CRP）,red blood cell distribution width（RDW）, neutrophil/lymphocyte ration（NLR）, platelet/lymphocyte ration（PLR）, CRP/albumin ration. Neutrophilic infiltration is associated with worse prognosis of HCC patients. It is found that increased numbers of CD4＋CD25＋FoxP3＋ Treg may bring about poor survival of HCC patients. Platelet is associated with development, growth, invasion and metastasis of HCC. Elevated level of serum CRP is associated with poor prognosis of patients with HCC. The patients with preoperative high RDW was poor survival. High NLR has been found that siginificantly associated with recurrence and prognosis of patients with HCC after curative resection. Elevated PLR is associated with overall survival overall survival, disease-free survivaland recurrence-free survival of patients with HCC. CRP/albumiration is an independent prognostic indicator of patients with HCCMentioned indicators above are lack of uniform standard. Specifimechanism is unclear. Here we review the research progress in thprognostic function of the peripheral blood relevant parameters iHCC.