MicroRNAs在非酒精性脂肪性肝病中作用的研究进展

Research progress on effect of microRNAs in the pathogenesis of nonalcoholic fatty liver disease

转录后的基因表达调控在疾病发生中起重要作用。MicroRNAs(miRNAs)是一类内源性高度保守的单链微小非编码小分子核糖核酸,长度约18-25个核苷酸的,可在转录后水平调节基因表达。研究发现,miRNAs可通过多个途径影响NAFLD的发生发展。文章从miRNAs调控脂质代谢、胰岛素抵抗、氧化应激、炎症反应、肠黏膜屏障、细胞凋亡等方面,对其在非酒精性脂肪性肝病发生发展中的作用进行综述。

Post-transcriptional regulation of gene expression is an important contributor to disease pathogenesis. MicroRNAs （miRNAs） are endogenous, conserved, single-stranded non-coding small RNA with 18-25 nucleotides in length, which regulate gene expression post-transcriptionally. Several studies found that miRNAs could affect the development of nonalcoholic fatty liver disease through multiple ways. This article reviews the roles of miRNAs in the development of nonalcoholic fatty liver disease by regulating lipid metabolism, insulin resistance, oxidative stress, inflammatory, intestinal mucosal barrier, cell apoptosis and so on.