白癜风人群戊型肝炎感染状况调查

Investigation of the infection status in patients with vitiligo

目的调查研究白癜风人群戊型肝炎的感染状况。方法对434例白癜风患者进行现况调查。收集患者血清并采用酶联免疫吸附测定(ELISA)方法进行抗戊型肝炎病毒(HEV)-IgG及抗HEV-IgM的检测,分析抗HEV-IgG阳性率与性别、年龄、病程及各免疫学指标之间的相关性。结果白癜风人群抗HEV-IgG阳性率为26.26%。成年及进展期白癜风患者抗HEVIgG阳性率远高于青少年和稳定期白癜风患者,差异有统计学意义(P<0.05)。IgG、IgA、C4检测水平异常患者抗HEV-IgG阳性率远高于这3项指标的正常水平者,差异有统计学意义(P<0.05)。抗HEV-IgM阳性者10人且均伴有抗HEV-IgG阳性。结论白癜风人群HEV感染率较高,有必要对该人群进行相应的HEV预防措施,从而降低此人群HEV的发病率。

Objective To investigate the infection status in patients with vitiligo.Methods A total of 434 patients with vitiligo were collected eligible data by a uniform questionnaire.Anti-HEV IgG and anti-HEV IgM were detected by enzyme-linked immunosorbent assay(ELISA).The correlation between the positive rate of anti-HEV IgG and sex,age,duration and immunology in-dex were analyzed.Results Out of the 434 patients,26.26% of the total subjects were anti-HEV IgG positive.The positivity of antiHEV IgG in adults and the progress of vitiligo patients was higher than that of teenagers and stabilization of vitiligo patients,the difference was statistically significant(P<0.05).Compared to the normal cases of IgA,IgG,C4,the positivity of anti-HEV IgG was significantly higher in the abnormal cases,the difference was statistically significant(P<0.05).Those 10 cases who were anti-HEV IgM positive,were anti-HEV IgG positive also.Conclusion The infection status in patients with vitiligo is serious and effective prevention strategies are required in future for reducing HEV transmission in these patients in order to reduce the incidence.