早产胎膜早破患者应用硫酸镁和盐酸利托君联合治疗的效果探讨

To investigate the treatment effect of combined application of magnesium sulfate and the ritodrine hydrochloride in patients with premature rupture

目的本文就不同用药方案治疗早产胎膜早破的临床价值及安全性进行了浅显的分析。方法随机将该院2014年10月至2016年10月收治的140例早产胎膜早破患者分为采用硫酸镁联合盐酸利托君治疗的观察组（n=70）及采用硫酸镁单用治疗的对照组（n=70），对两组患者用药后的临床效果，宫缩抑制时间、孕龄延长时间及药物显效所用时间，药物不良反应发生率，分娩方式及新生儿并发症等指标进行观察和统计。结果观察组用药后临床总有效率及阴道分娩率明显高于对照组（P〈0．05）；观察组宫缩抑制时间、孕龄延长时间及药物显效所用时间明显优于对照组（P〈O．05）观察组药物不良反应发生率及新生儿并发症发生率明显低于对照组（P〈0．05）。结论硫酸镁联合盐酸利托君治疗早产胎膜早破的临床效果显著，有效提高了分娩质量，提高了分娩的安全性，值得推广。

Objective This article analyzed the clinical value and safety of different medication regimens in the treatment of pre- term premature rupture of membranes. Methods 140 cases of preterm premature rupture of membranes treated in our hospital from October 2014 to October 2016 Prom were divided into the observation group using Magnesium Sulfate combined with ritodrine hydrochloride therapy（n= 70） and the Magnesium Sulfate with the treatment of control group（n： 70）, the clinical effect of two groups of patients after treatment, uterine contraction time, gestational age prolonged inhibition the time for the time and drug effect, the incidence of adverse drug reactions, index of the mode of delivery and neonatal complications were observed. Results in the observation group,the total effective rate and the rate of vaginal delivery after treatment was significantly higher than the con- trol group （P〈0.05） ;in the observation group contractions extend time and the time for the drug was significantly better than the control group, the inhibition time of gestational age （P〈0.05）, the incidence of drug adverse reaction group and neonatal complica- tions was significantly lower than the control group（P〈0.05）. Conclusion the clinical effect of Magnesium Sulfate combined with ritodrine hydrochloride in the treatment of preterm premature rupture of membranes significantly,effectively improve the quality of delivery,improve the safety of labor,thus it is worthy of promotion.