间充质干细胞组织特异性归巢的研究进展

Advances in research for the organ-specific migration of mesenchymal stromal cells

间充质干细胞(MSCs)是一种非造血组织的多能干细胞,具有自我更新和多向分化的潜能,在机体组织再生和炎症控制的过程中发挥关键作用。其中,以MSCs为基础的治疗,其疗效至少部分取决于对所需细胞部位的特定归巢。然而,最近许多研究发现MSCs对不同组织的归巢特性存在差异,在一定程度上影响了MSCs发挥治疗作用。因此本文对MSCs在骨髓、脾和淋巴结、肠、心脏、肿瘤、多脏器的归巢现象和治疗作用、归巢的影响因素以及体内示踪技术进行了综述。

As non- hcmatopoietic multipotent stem cells, mesenchymal stem cells （MSCs） with the potential of selfrenewal and multi - direc- tional differentiation, play a key role in the process of tissue regenerations and anti - inflammation. In the case, the efficacy of these MSC - based therapies at least partly depends on specific homing towards the site where the cells are needed. Nowdays, many studies find that the different homing characteristics in different organizations, which limits the thera- peutic efficacy when they are used in stem cell therapy. Thus,the homing phenomena, the therapeutical efficacy, the influencing factors and the cell tracing techniques of MSCs in bone marrow, spleen and lymph nodes, intes- tine, heart, cancer and multiple organ are reviewed in the article.