白细胞介素-10基因多态性与侵袭性牙周炎相关性的系统评价

Association between interleukin-10 gene polymorphism and aggressive periodontitis:a systematic review

目的:系统评价白细胞介素-10(interleukin-10,IL-10)基因rs1800872、rs1800871和rs1800896位点单核苷酸多态性(single nucleotide polymorphisms,SNP)与侵袭性牙周炎(aggressive periodontitis,AgP)相关性。方法:计算机检索Pub Med、Web of Science、Embase、The Cochrane Library、中国生物医学文献数据库、中国期刊全文数据库、中国科技期刊数据库及万方数字化期刊全文数据库,收集关于IL-10基因rs1800872、rs1800871和rs1800896位点SNP与AgP相关性的病例-对照研究,检索时限均为从建库至2015年8月。由2位研究者按照纳入与排除标准独立筛选文献、提取资料并评价纳入研究的方法学质量后,采用Rev Man 5.3软件进行Meta分析。结果:共纳入11个病例-对照研究,其中rs1800872:病例组389例,对照组570例;rs1800871:病例组380例,对照组553例;rs1800896:病例组526例,对照组745例。Meta分析结果显示,IL-10基因rs1800872、rs1800871和rs1800896位点SNP与AgP无统计学相关性。结论:IL-10基因rs1800872、rs1800871和rs1800896位点SNP可能与AgP无相关性。

Objective：To systematically review the association between interleukin-10（IL-10）gene rs1800872,rs180087 and rs1800896 single nucleotide polymorphisms（SNP）and aggressive periodontitis（AgP）. Methods：Databases as Pub Med,Web of Science,Embase,The Cochrane Library,Chinese biomedical literature database,CNKI,VIP and Wan Fang digital journals were electronically searched to collect case-control studies published up to August 2015 about the association between IL-10 gene rs1800872,rs180087 and rs1800896 SNP and AgP. According to inclusion and exclusion criteria,two reviewers independently screened literature,extracted data,and assessed methodological quality of included studies. Then meta-analysis was performed using Rev Man 5.3 software. Results：A total of 11 case-control studies were included. Specifically,there were 389 subjects in case group and 570 subjects in control group from rs1800872;380 subjects in case group and 553 subjects in control group from rs1800871;526 subjects in case group and 745 subjects in control group from rs1800896. The results of meta-analysis showed that,no significant association was found between IL-10 gene rs1800872,rs180087 and rs1800896 SNP and AgP in the total analysis. Conclusion：IL-10 gene rs1800872,rs180087 and rs1800896 SNP may not be associated with AgP.