摘要
慢加急性肝衰竭（ACLF）是我国及亚太地区慢性肝病患者常见的危急重症，近年来，东西方学者均认为ACLF是一种新的肝病类型，显著特点表现为28d病死率高（〉30％）和高强度的全身炎症反应。ACLF已成为肝病领域的热点问题之一，现简要回顾ACLF的定义及病因变迁方面的研究进展，同时分析探讨近期新认识对未来研究的启示。
Acute-on-chronic liver failure （ACLF） is a common critical and severe syndrome in patients with chronic liver diseases in China and other countries in the Asia-Pacific region. In recent years, both the Eastern and Western experts have defined ACLF as a new type of liver disease manifesting as a high 28-day mortality rate （〉30%） and extensive systematic inflammatory response. ACLF has become a hot topic in the field of liver diseases. This article reviews the research advances in the definition and etiological spectrum of ACLF and discusses the inspirations of such new knowledge for future research.
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2017年第9期659-663,共5页
Chinese Journal of Hepatology
基金
传染病国家科技重大专项（2017ZX10203203-002-003）
国家自然科学基金重点项目（81330038）
重庆市前沿与应用基础研究计划项目（CSTC2014jcyjA10114）
关键词
肝功能衰竭
肝炎
乙型
慢性
肝硬化
Liver failure
Hepatitis B, chronic
Liver cirrhosis
