硫氧还蛋白在心肌疾病及其能量代谢中的作用

The role of thioredoxin in myocardial diseasesand energy metabolism

硫氧还蛋白(thioredoxins,Trx)作为一个抗氧化分子,广泛存在于多种生物体中。越来越多的研究表明,Trx在包括氧化还原调节等多种生理过程中存在广泛作用。充血性心力衰竭是多种心血管疾病的表现之一,可能通过Trx活性的抑制和活性氧的减少来降低氧化应激而使症状加剧。硫氧还蛋白互作蛋白通过抑制Trx的活性,干扰Trx绑定其他信号分子的能力,影响细胞中的葡萄糖摄取,以阻碍其生理功能。文章主要以动物体Trx为研究对象,对其分类、理化性质、生物学功能、与活性氧(reactive oxygen species,ROS)的关系及在心肌疾病能量代谢中的作用进行了阐述。

Thioredoxins（Trx） ,anantioxidant moleculeexisted in variety of organismsextensively. Reported results froma growing number of stud- ies suggested that Trxtook wide part in various physiological precessesincluding redox regulation. Congestive heart failure was one of the manifestations of various cardiovascular diseases,which could be exacerbated bythe reduction of oxidative stress via the inhibition of Trx and the decrease of reactive oxygen species. Thioredoxininteracting protein could inhibit the ability of Trx and disturbedTrx to bind ＇other signaling molecules, and then affected glucose extraction in cellsleading to hindering its physiological functions. Trx from animal was chosen to be the target in this paper, and its classification, physicochemieal characteristics, biological functions and the relationship with reactive oxygen species（ROS） werediscussed as well as the role of Trx in myocardial diseasesand energy metabolism.