治疗功能性消化不良合并焦虑抑郁的临床用药探讨

Clinical Study on the Treatment of Functional Dyspepsia With Anxiety and Depression

目的探讨功能性消化不良合并焦虑抑郁的临床用药。方法选取我院治疗功能性消化不良合并焦虑抑郁的患者作为研究对象,将其分为:研究组(治疗方案为莫沙必利+雷贝拉唑+氟西汀)和对照组(治疗方案为莫沙必利+雷贝拉唑)。对比两组治疗前后焦虑、抑郁评分及消化道症状评分以及临床疗效。结果两组治疗前焦虑、抑郁评分及消化道症状评分比较,差异不具有统计学意义(P>0.05);治疗后,两组患者焦虑、抑郁评分及消化道症状评分比较,差异均具有统计学意义(P<0.05);两组患者的临床疗效比较,差异具有统计学意义(P<0.05)。结论莫沙必利与雷贝拉唑联合氟西汀治疗功能性消化不良合并焦虑抑郁患者疗效肯定。

Objective To explore the clinical medication of functional dyspepsia combined with anxiety and depression. Methods Patients with functional dyspepsia combined with anxiety and depression in our hospital as the research object and were divided into： the study group （treatment with Mosapride ＋ Rabeprazole with Fluoxetine） and control group （treatment with Mosapride ＋ Rabeprazole）. The scores of anxiety, depression and gastrointestinal symptoms before and after treatment and the clinical efficacy of the two groups were compared between the two groups. Results Comparison of the two groups before treatment, the scores of anxiety and depression and gastrointestinal symptom score, the difference was not statistically significant （P〉0.05）. After treatment, compared two groups of patients with anxiety and depression score and gastrointestinal symptom score, the difference was statistically significant （P〈0.05）. The clinical efficacy of the two groups was statistically significant （P〈0.05）. Conclusion Mosapride and Rabeprazole plus Fluoxetine in the treatment of functional dyspepsia with depression and anxiety in patients with curative effect.