亚甲蓝示踪剂在乳腺癌前哨淋巴结活检中的应用

Application of Methylene Blue in Breast Cancer Sentinel Lymph Node Biopsy

目的:探讨亚甲蓝作为示踪剂在乳腺癌前哨淋巴结(sentinel lymph node,SLN)活检中的应用价值,并评价前哨淋巴结预测腋窝淋巴结转移的准确性。方法:收集2012年6月-2015年6月本院收治的100例临床分期为Ⅰ、Ⅱ期的乳腺癌患者,前哨淋巴结活检后均行腋窝淋巴结清扫。结果:91例患者中成功地检测出188枚SLN,平均每例(2.00±0.09)枚。乳腺癌前哨淋巴结活检术(sentinel lymph node biopsy,SLNB)的灵敏度91.0%(91/100),准确率96.7%(88/91),假阴性率7.3%(3/41),灵敏度为92.7%(38/41)。结论:亚甲蓝作为乳腺癌前哨淋巴结活检的示踪剂安全、可靠,能准确找到前哨淋巴结,并能较好的预测腋窝淋巴结转移情况。

Objective： To study the value of Methylene blue as a tracer in breast cancer sentinel lymph node （ sentinel lymph node, SLN ） biopsy, and evaluating the accuracy of the sentinel lymph node predicting axillary lymph node metastasis.Method： From June 2012 to June 2015, 100 patients with stage I, II breast cancer were selected, all the patients were given axillary lymph node dissection after sentinel lymph node biopsy.Result： 91 patients were detected SLNS successfully, the total number of SLNS was 188, the average was （ 2.00 ±0.09 ） case.SLNS biopsy sensitivity rate was 91.0% （ 91/100 ）, the accurate rate was 96.7% （ 88/91 ）, the false negative rate was 7.3% （3/41）, the sensitivity was 92.7% （38/41） .Conclusion： Methylene blue as an tracer for breast cancer sentinel lymph node biopsy is safe and reliable, can find the sentinel lymph node accurately, and predict axillary lymph node metastasis well.