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经介入途径多疗法、多基因联合治疗肝癌的可行性分析

Feasibility Analysis of Combined Therapy and Multiple Gene Therapy for Hepatocellular Carcinoma
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摘要 目的:分析探讨经介入途径多疗法、多基因联合治疗肝癌的可行性。方法:选取2013年11月-2016年11月120只大白兔建立肝癌模型,按照随机数字表法分为五组,每组24只。第一组为单纯超液化碘油栓塞组,第二组为超液化碘油+P53(质粒-脂质体复合物)组,第三组为超液化碘油+TK/CD(浓缩的TK-CD逆转录病毒上清),第四组为超液化碘油+P53+TK/CD组,第五组仅进行生理盐水治疗(对照组)。对五组大白兔进行常规的病理检查和生存期观测。结果:各治疗组肿瘤体积增长率均较对照组明显下降,其中第四组肿瘤增长率抑制最为有效,差异均有统计学意义(P<0.05);对照组瘤兔介入术后20~40 d相继全部死亡,治疗组在观察期内自然死亡30只(31.3%),第一组12只(50.0%),第二组9只(37.5%),第三组7只(29.2%),第四组2只(8.3%),五组瘤兔生存情况比较差异均有统计学意义(P<0.05)。结论:介入基因疗法能够克服介入治疗的副作用,有效地抑制肿瘤的生长,延长瘤兔的生存时间。 Objective: To investigate the feasibility of combined therapy and multiple gene therapy in the treatment of liver cancer.Method: A total of 120 rabbits from November 2013 to November 2016 were selected to establish the model of liver cancer, and they were randomly divided into 5 groups according to random number table method, 24 cases in each group.The first group was given pure lipiodol embolization group, the second group was given lipiodol+P53 ( plasmid liposome complex ) group, the third group was lipiodol+TK/CD ( TK-CD retrovirus supernatant concentration ), the fourth group was given lipiodol+P53+TK/CD group, the fifth group only saline the treatment ( control group ) .Five groups were examined by routine pathology and their lifetime were observed.Result: Compared with the control group, the tumor volume growth rate of the other groups decreased significantly, the fourth group was the most effective, the differences were statistically significant (P〈0.05) . Rabbits of the control group had all died after PCI 20-40 days, natural death of the other grouPs inthe observation period was 30 cases ( 31.3% ), the first group was 12 cases ( 50.0% ), the second group 9 cases ( 37.5% ), the third group was 7 cases ( 29.2% ), the fourth group was 2 cases ( 8.3% ), the differences were statistically significant ( P〈0.05 ) .Conclusion: Interventional gene therapy can overcome the side effects of interventional therapy, effectively inhibit the grola of tumor and prolong the survival time of tumor rabbits.
出处 《中国医学创新》 CAS 2017年第26期29-32,共4页 Medical Innovation of China
关键词 介入 多基因 肝癌 可行性 Intervention Polygene Liver cancer Feasibility
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