慢性萎缩性胃炎患者G-17、CA19-9及胃蛋白酶原比值的变化分析

Serum levels of gastrin 17 and CA19-9 and pepsinogen ratio in patients with chronic atrophic gastritis

目的分析慢性萎缩性胃炎（CAG）患者血清胃泌素17（G-17）、血清糖类抗原19—9（CA19-9）及胃蛋白酶原（PG）比值的变化规律。方法选取2014年1至12月在本院确诊并接受治疗的慢性萎缩性胃炎患者79例为观察组，选取同期在本院接受治疗的慢性非萎缩性胃炎患者95例作为对照组。计算患者血清PGⅠ、Ⅱ的比值，对比两组患者以及观察组不同萎缩程度患者问的血清G-17、CA19—9水平以及PGⅠ、Ⅱ比值情况。结果慢性萎缩性胃炎患者的血清胃泌素17和CA19—9的水平明显高于慢性非萎缩性胃炎患者；慢性萎缩性胃炎患者的PGI水平明显低于慢性非萎缩性肺炎患者；血清胃泌素17和CA19—9的平均水平随CAG患者萎缩程度的加重而升高、PGI的平均水平随患者萎缩程度的加重而降低；两组患者的PGⅡ水平和胃蛋白酶比值没有明显差距。结论血清胃泌素17和CA19—9的高表达与胃蛋白酶原水平的下降是慢性萎缩性胃炎的标志，对于诊断慢性萎缩性胃炎具有重要意义，值得综合应用。

Objective To analyze the serum levels of gastrin 17 （G-17） and CA19-9 and pepsinogen ratio in patients with chronic atrophic gastritis. Methods 79 patients with chronic atrophic gastritis treated at our hospital from January to December, 2014 were selected as an observation group and 95 with chronic non-atrophic gastritis a control group. The serum levels of G-17, CA19-9, PGⅠ, and PGⅡ were detected and calculated. Results The serum levels of G-17 and CA19-9 were higher and the PGⅠ level was lower in the observation group than in the control group. The serum levels of G-17 and CA19-9 increased and the PGⅠ level decreased with the severity of chronic atrophic gastritis. There were no statistical differences in PGⅡ level and pepsinogen ratio between these two groups. Conclusions The increase of the serum levels G-17 and CA19-9 and the decrease of pepsinogen indicate chronic atrophic gastritis and has diagnostic value for chronic atrophic gastritis and pepsinogen ratio is low, so it is worth for comprehensive application.