大腿丛状神经鞘瘤1例

A case of plexiform schwannoma in top-thigh

目的探讨大腿根部丛状神经鞘瘤的临床及病理特点。方法报告1例大腿丛状神经鞘瘤并进行相关文献复习。结果63岁女性患者，因发现左大腿根部肿物2年余人院，人院后完善相关检查，行手术切除肿物。组织病理检查示真皮层深部多结节状肿物，每个结节均有完整的纤维包膜，结节主要由许多梭形细胞组成，多呈短束状，可见verocay小体，偶见核分裂像，结节间多为疏松的纤维性间质，免疫组化示S-100蛋白阳性，而SMA、NF及Ki-67均阴性，病理诊断：丛状神经斡i瘤。结论丛状神经鞘瘤是一种较少见的外周神经肿瘤，在临床工作中根据其典型病理表现，注意与丛状神经纤维瘤等疾病鉴别。

Objective To investigate the clinical and pathological features ofplexiform schwannoma in top-thigh. Methods A case of plexiform schwannoma in top-thigh was reported and the related literatures were reviewed. Results The patient （female, 63 years old） came to hospital because a mass was found in the top of her left thigh. After being hospitalized, routine laboratory tests were taken and the mass was removed completely. Pathological examination showed a multinodular mass in the deep dermis and every nodule had complete envelope; besides there was loose fibrous stroma between nodules. The nodule was composed of spindle cells in which verocay corpuscles and mitotic figures could be seen occasionally. Immunohistochemistry showed that S-100 protein was positive, while SMA, NK, and Ki-67 negative. Finally, the pathologic diagnosis was plexiform schwannoma： Conclusions Plexiform schwannoma is a kind of rare peripheral nerve tumor, which has special pathological characteristics. Plexiform schwannoma should be identified from plexiform neurofibroma during our clinical work.