血浆胸腺基质淋巴细胞生成素在毛细支气管炎中的意义

Significance of plasma thymic stromal lymphopoietin in bronchiolitis patients

目的探讨血浆胸腺基质淋巴细胞生成素（thymic stromal lymphopoietin，TSLP）在首次罹患毛细支气管炎患儿发病过程中的意义。方法首次喘息，临床诊断为毛细支气管炎的患儿共50例，男34例，女16例，平均年龄（7．0±4．8）个月；同期体检健康的婴儿25例，男19例，女6例，平均年龄（7．2±4．0）个月。就诊婴儿分别于就诊当日采集3ml外周静脉血，分离血浆，并采用ELISA法检测TSLP。结果毛细支气管炎患儿血浆TSLP为（0．271±0．073）ng／ml，健康婴儿血浆TSLP为（0．211±0．084）ng／ml，差异有统计学意义（P〈O．05）。结论毛细支气管炎患儿血浆TSLP明显升高，TSLP参与毛细支气管炎的发病过程。

Objective To explore the role of plasma thymic stromal lymphopoietin （TSLP） in newly detected bronchiolitis patients. Methods The levels of plasma TSLP in 50 infants with bronchiolitis [34 male and 16 female, the average age was （7.0±4.8） monthsl and 25 healthy infants [19 male and 6 female, the average age was （7.2±4.0） months] were detected by ELISA. Results The level of plasma TSLP in infants with bronchiolitis was （0.271±0.073） ng/ml, that in healthy infants was （0.211±0.084） ng/ml, with statistically significant difference （P〈0.05）. Conclusion TSLPparticipates the pathogenesis ofbronchiolitis.