摘要
通过X-ray单晶衍射表征药物(3E,5E)-N-苄基-3,5-二(4-羟基苯亚甲基)-4-哌啶酮盐酸盐(A)的结构。A(C_(26)H_(24)ClNO_3,Mr=433.91)结晶在triclinic晶系,P-1空间群,a=9.8813(4),b=11.1292(4),c=12.9552(5)?,α=98.058(3)°,β=108.134(4)°,γ=107.353(3)°,U=1248.93(8)?~3,Z=2。CCK-8法评价其对A549、SGC-7901、HePG2、Hela、K562等肿瘤细胞系的抗肿瘤活性及对正常细胞HUVEC的细胞毒性。结果显示,A对SGC7901、K562和Hela的活性较好,其中对K562的抑制活性最好,IC50=7.86μM。并且对正常细胞HUVEC的细胞毒性较小。
（ 3E,5E）-N-benzyl-3,5-bis（ 4-hydroxybenzylidene）-4-Piperidone（ A） was characterized by X-ray diffractometer. A（ C_（26）H_（24）ClNO_3,Mr = 433. 91） belongs to the triclinic system,space group P-1 with a = 9. 8813（ 4）,b =11. 1292（ 4）,c = 12. 9552（ 5） ？,α = 98. 058（ 3） °,β = 108. 134（ 4） °,γ = 107. 353（ 3） °,U = 1248. 93（ 8） ？~3,Z = 2.The antitumor activities against human neoplastic cell lines A549,HePG2,MCF-7,SGC-7901,OVCA-433 and the cytotoxicity for HUVEC cell lines by CCK-8 method were subsequently evaluated. The antitumor activities against SGC7901,K562 and Hela were better with the lower cytotoxicity against HUVEC cell,while the best one was K562 cells,which IC50= 7. 86μM.
出处
《山东化工》
CAS
2017年第16期1-2,4,共3页
Shandong Chemical Industry
基金
山东省自然科学基金(No.ZR2014BL008)
烟台市科技计划(2015WS010)
关键词
Α
Β-不饱和酮
抗肿瘤
单晶结构
α
β-unsaturated ketone
antitumor
single-crystal structure
