紫河车免煎颗粒对温和刺激方案结局的影响

Effects of Placenta Granules on outcome of mild stimulation protocol

目的观察紫河车免煎颗粒(紫河车)对子宫内膜容受性以及胚胎结局的影响。方法将符合肾气虚型的90例不孕患者随机分为对照组和紫河车组(治疗组),观察两组的子宫内膜厚度、形态、血流、取卵数、受精数、发育胚胎数、优质胚胎数、妊娠率、着床率、流产率。结果两组患者在血流、发育胚胎数、优质胚胎数上有显著差异(P<0.05)。对照组10例以及治疗组14例达到鲜胚移植标准;对照组人体绒膜促性腺激素(HCG)阳性人数4例,低于治疗组6例;对照组临床妊娠人数3例,治疗组6例;对照组种植率4例,治疗组9例。差异均无统计学意义(P>0.05)。结论紫河车免煎颗粒可以改善温和刺激方案下促排卵周期子宫内膜容受性及优质胚胎数,显示出增加临床妊娠率的趋势。

AIM To observe the effects of Placenta Granules（ Hominis placenta） on endometrial receptivity and embryo outcome. METHODS Ninety infertile patients meeting the kidney Qi deficiency syndrome were randomly divided into H. placenta group（ treatment group） and control group. The endometrial thickness,endometrial morphology,blood flow,ovum pick-up number,fertilization number,developmental embryo number,highquality embryo number,pregnancy rate, implantation rate and abnormal pregnancy rate were observed in the two groups. RESULTS There were significant differences in blood flow,numbers of developmental embryo and high-quality embryo（ P 0. 05）. Ten cases in the control group and fourteen cases in the treatment group reached standard for fresh embryo transplantation. The number of HCG positive in the control group was four cases,which was lower than six cases in the treatment group. There were three cases in the control group on number of clinical pregnancy,and six cases in the treatment group. There were four cases in the control group on implantation rate,and nine cases in the treatment group. All the differences were not statistically significant（ P 0. 05）.CONCLUSION Placenta Granules can improve the endometrial receptivity and high-quality embryo number in ovarian-stimulation stage under mild stimulation protocol,showing a rising trend in clinical pregnancy rate.