胎盘多肽注射液联合唑来膦酸治疗骨转移癌的临床研究

The Placenta Polypeptide Injection Injection Combined Azole Phosphonic Acid Clinical Research for the Treatment of Bone Metastatic Carcinoma

目的观察胎盘多肽注射液联合唑来膦酸治疗骨转移癌的临床疗效及安全性,为骨转移癌的治疗提供临床借鉴。方法选择60例骨转移癌患者,按照随机数字法将患者分为观察组与对照组,每组30例,对照组采用唑来膦酸治疗,观察组采用唑来膦酸注射液联合胎盘多肽注射液治疗,两组患者共治疗3个周期,第4个治疗周期作为随访资料。比较两组患者治疗前后疼痛评分,治疗过程中的不良反应,治疗结束的临床疗效。结果两组患者治疗后疼痛评分均较治疗前明显降低,治疗前后比较差异有统计学意义(P<0.05);观察组临床总有效率明显高于对照组患者,组间比较差异有统计学意义(P<0.05);两组患者治疗后生活质量评分KPS均较治疗前提高,治疗前后比较差异均有统计学意义(P<0.05),但观察组患者治疗后KPS评分明显高于对照组,组间比较差异有统计学意义(P<0.05)。治疗过程中,两组均有数例患者发生发热、肌肉酸痛等流感样症状,给以非甾体类消炎药等常规处理后缓解,两组比较无显著性差异(P>0.05);实验室指标监测未发现血常规及肝、肾功能、心电图异常改变(原有异常者未加重)。结论胎盘多肽注射液联合唑来膦酸治疗骨转移患者,不仅可以增强免疫、抗肿瘤,而且可以促进骨转移的愈合,减轻疼痛,降低骨相关事件的发生率,值得临床推广应用。

Objective To observe the placenta polypeptide injection combined azole phosphate treatment clinical curative effect and safety of bone metastatic carcinoma,and provide clinical reference for the treatment of metastatic carcinoma of bone. Methods 60 cases of patients with bone metastasis cancer,according to the random number method were divided into the observation group and the control group,30 cases in each group,the control group adopted the azole phosphonic acid injection treatment,the observation group adopted the azole phosphonic acid injection with placenta polypeptide injection injection therapy,two groups of patients with a total of three treatment cycles,the fourth treatment cycle as the follow-up data. Compare the 2 groups before and after treatment in patients with pain score,the adverse reaction in the process of treatment,treatment of the clinical curative effect of the end. Results The 2 groups after treatment in patients with pain score was significantly decreased,and the comparison before and after treatment was statistically significant difference（ P〈0. 05）; Observation group of patients clinical total effective rate was significantly higher than the control group patients,there was statistically significant difference（ P〈0. 05）; Quality of life score KPS after treatment in both groups was improved,and the comparative differences before and after the treatment were statistically significant（ P〈0. 05）,but the observation group of patients after treatment KPS score significantly higher than the control group,compare the difference between groups was statistically significant（ P〈0. 05）. Treatment process,in both groups have flu-like symptoms such as fever,muscle aches,non-steroidal anti-inflammatory drugs and other conventional treatment relief,after comparing the 2 groups have no significant difference（ P〉0. 05）; Laboratory indicators monitoring found no abnormal changes of blood routine,liver and kidney function,electrocardiogram（ ecg）（ original abnormal not heavier）. Conclusion Placenta polypeptide injection injection combined azole phosphonic acid treatment for patients with bone metastases,can enhance immunity,antitumor,and can promote the healing of bone metastases,relieve pain,reduce the incidence of bone related events,it is wor thy of clinical popularization and application.