摘要
三磷酸腺苷(Adenosine triphosphate,ATP)是机体内一种重要的内源性损伤相关分子模式(Damage-associated molecular pattern,DAMP)。嘌呤受体P2X_7(Purinergic receptor,P2X_7R)是以ATP为配体的离子门控通道,在多种疾病的病理生理过程中发挥着重要作用。因P2X_7R表达于多种免疫细胞表面,ATP-P2X_7R信号转导途径成为机体对抗病原体的重要组成部分。本文主要就ATP-P2X_7R信号通路及其在寄生虫感染中的作用和机制作一综述。
ATP （Adenosine triphosphate） is an important endogenous damage-associated molecular pattern （DAMP）. P2X7R is an ATP-gated cation channel. ATP-P2X7R plays a vital role in the pathophysiology of many diseases because P2X7R is distributed on various immune cells. ATP-P2X7R signal transduction pathway has been implicated to participate in the body＆#39;s im-mune defense against pathogens. This paper reviews the recent progress regarding ATP-P2X7R and its effects on parasitic diseas-es.
出处
《中国血吸虫病防治杂志》
CAS
CSCD
北大核心
2017年第4期526-529,共4页
Chinese Journal of Schistosomiasis Control
