病毒性脑炎患儿脑脊液和血清中IFN-α和S100B蛋白的表达及临床意义

Expression and Clinical Significance of IFN-α and S100B Proteins in Cerebrospinal Fluid and Serum of Children with Viral Encephalitis

目的:探讨病毒性脑炎患儿脑脊液和血清中α干扰素(IFN-α)和S100B蛋白水平及临床意义。方法:选择我院收治的病毒性脑炎患儿80例为研究组,同时纳入50例体检健康儿童为对照组。比较两组儿童不同症状、阶段及预后患儿脑脊液和血清中IFN-α和S100B蛋白水平。结果:与对照组比较,研究组患儿脑脊液和血清IFN-α和S100B蛋白水平均显著升高,差异有统计学意义(P<0.01);重症组患儿脑脊液和血清中IFN-α和S100B蛋白水平显著高于轻症组(P<0.01);恢复期患儿脑脊液和血清中IFN-α和S100B蛋白水平显著低于急性期(P<0.01)。1年随访发现,预后差的患儿在入院时脑脊液和血清中IFN-α和S100B蛋白水平显著高于预后良好患儿(P<0.01)。多元线性回归分析显示,重症及急性期为IFN-α和S100B蛋白水平升高的独立影响因素(P<0.05)。结论:脑脊液和血清中IFN-α和S100B蛋白水平变化对评价病毒性脑炎的病情、预后有重要临床价值。

Objective：To investigate the clinical significance and expression of IFN-α and S100B proteins levels in cerebrospinal fluid and serum in children with viral encephalitis.Methods：Eighty children with viral encephalitis were selected as observation group from our hospital,and at the same time 50 healthy children were selected as control group.The levels of IFN-α and S100B proteins in cerebrospinal fluid and serum were compared between the two groups.The levels of IFN-α and S100B proteins in cerebrospinal fluid and serum were compared in different symptoms,phases and prognosis.Results：Compared with the control group,the levels of IFN-α and S100B proteins in cerebrospinal fluid and serum in observation group were significantly increased,the differences were statistically significant（P〈0.01）.The levels of IFN-α and S100B proteins in cerebrospinal fluid and serum in severe group were significantly higher than the mild group（P〈0.01）.The levels of IFN-α and S100B proteins in cerebrospinal fluid and serum in recovery phase were significantly lower than those in acute phase（P〈0.01）.The 1 year follow-up showed that the levels of IFN-α and S100B proteins in cerebrospinal fluid and serum of children with poor prognosis were significantly higher than those with good prognosis（P〈0.01）.Multivariate linear regression analysis showed that the severe and acute phases were independent risk factors affecting the rise of IFN-αand S100B proteins levels（P〈0.05）.Conclusion：The changes of IFN-α and S100B proteins in cerebrospinal fluid and serum have important clinical value in the evaluation of the condition and prognosis of viral encephalitis.