小剂量红霉素联合酪酸梭菌活菌散治疗新生儿围生期窒息后喂养不耐受

Small Dosage of Erythromycin Combined with Clostridium Butyricum Powder(Live) in Treatment with Feeding Intolerance in Perinatal Asphyxia Neonate

目的:探讨小剂量红霉素联合酪酸梭菌活菌散治疗新生儿围生期窒息后喂养不耐受的临床效果。方法:选取2014年1月至2016年6月我院新生儿病房诊治的喂养不耐受患儿240例,随机分为三组各80例,分别给予红霉素(红霉素组)、酪酸梭菌活菌散(酪酸梭菌活菌散组)、小剂量红霉素联合酪酸梭菌活菌散(联合组),比较三组患儿的临床疗效及不良反应发生情况。结果:红霉素组患儿无效11例(13.75%),酪酸梭菌活菌散组患儿无效13例(16.25%),联合组患儿无效2例(2.50%),三组患儿比较差异有统计学意义(P<0.05),红霉素组与酪酸梭菌活菌散组比较差异无统计学意义(χ~2=0.438,P>0.05);红霉素组与联合组比较差异有统计学意义(χ~2=6.945,P<0.05);酪酸梭菌活菌散组与联合组比较差异有统计学意义(χ~2=9.721,P<0.05);联合组患儿呕吐次数、胃残余奶量、腹胀持续时间均低于红霉素组和酪酸梭菌活菌散组,日增加奶量、平均增加体质量均高于红霉素组和酪酸梭菌活菌散组,差异有统计学意义(P<0.05);红霉素组、酪酸梭菌活菌散组、联合组患儿不良反应发生率分别为3.75%、3.75%、2.50%,差异无统计学意义(P>0.05)。结论:小剂量红霉素联合酪酸梭菌活菌散治疗新生儿围生期窒息后喂养不耐受效果明显,且具有较好的安全性,值得临床推广应用。

Objective：To investigate the effect of small dosage of erythromycin combined with clostridium butyricum powder（live） in treatment with feeding intolerance in perinatal asphyxia neonate.Methods：Two hundreds and forty neonates with feeding intolerance were selected from January 2014 to June 2016 in our hospital.They were divided into three groups,erythromycin group,clostridium butyricum powder（live） group and combined treatment group,each group had 80 cases.Each group was given erythromycin,clostridium butyricum powder（live） and small dosage of erythromycin combined with clostridium butyricum powder（live） respectively.Clinical effect and adverse reactions were compared.Results：There were 11 cases（13.75%） ineffective treatment in erythromycin group,13 cases（16.25%） in clostridium butyricum powder（live） group and 2 cases（2.50%） in combined treatment group,the differences had statistical significance（P〈0.05）.In the combined treatment group,vomitive times,residual amount of milk,duration of abdominal distention were lower than erythromycin group and clostridium butyricum powder（live） group,the differences had statistical significance（P〈0.05）.The incidence of adverse reactions in the erythromycin group,clostridium butyricum powder（live）group and combined treatment group were 3.75%,3.75%,2.50%,the differences had no significance（P〈0.05）.Conclusion：Small dosage of erythromycin combined with clostridium butyricum powder（live） in treatment with feeding intolerance in perinatal asphyxia neonate have obvious curative effect and security,it is deserve the clinical expansion.