新生儿监护病房无乳链球菌临床分布及耐药性分析

Clinical distribution and antimicrobial resistance of Streptococcus agalactiae in neonatal intensive care unit

目的了解医院新生儿监护病房无乳链球菌临床分布及采取耐药性,为抗菌药物的使用及采取干预措施提供参考依据。方法收集2010—2014年某院新生儿监护病房新生儿送检的标本,对新生儿分离的62株无乳链球菌来源科室和药敏试验结果进行分析。结果 62株无乳链球菌的科室分布以足月新生儿监护病房为主,占64.52%;标本来源以血为主,占90.33%,其次为脑脊液(6.45%)、痰和分泌物(均为1.61%)。无乳链球菌对四环素的耐药率最高,为79.03%;对红霉素和克林霉素的耐药率均为74.19%,对左氧氟沙星的耐药率为40.32%,对青霉素、氨苄西林100%敏感。结论无乳链球菌感染在新生儿监护病房中以足月新生儿监护病房为主,对多种抗菌药物有较高的耐药率,青霉素和氨苄西林可作为治疗无乳链球菌感染的优选药物。

Objective To investigate the clinical distribution and antimicrobial resistance of Streptococcus agalactiae（S.agalactiae） in neonatal intensive care unit（NICU）, and provide reference for antimicrobial use and intervention measures.Methods Specimens from neonates in the NICU of a hospital in 2010-2014 were collected, the department sources and antimicrobial susceptibility testing results of 62 strains of S.agalactiae isolated from children were analyzed.Results 62 strains of S.agalactiae were mainly distributed at full-term NICU, accounting for 64.52%;the main source of specimens was blood, accounting for 90.33%, followed, by cerebrospinal fluid （6.45%）, sputum, and secretion（both were 1.61%）.S.agalactiae had the highest resistance rate to tetracycline（79.03%）;resistance rates to erythromycin and clindamycin were both 74.19%, resistance rate to levofloxacin was 40.32%, susceptibility rates to penicillin and ampicillin were both 100%.Conclusion S.agalactiae infection mainly occurred in neonates in full-term NICU, and has high resistance rate to multiple antimicrobial agents, penicillin and ampicillin can be used as the preferred antimicrobial agents for the treatment of S.agalactiae infection.