RANTES、MCP-1和SDF-1β在正常人体和AIDS患者体内含量的对比研究

RANTES,MCP-1,and SDF-1βlevels in healthy people and AIDS patients:a comparative analysis

目的探讨血清趋化因子(RANTES)、单核细胞趋化蛋白1(MCP-1)、基质细胞衍生因子-1β(SDF-1β)在获得性免疫缺陷综合征(AIDS)和正常人体内的差异。方法选择2010年1月—2015年1月某院收集的38例AIDS患者作为AIDS组,38例健康者作为健康组,检测两组血清RANTES、MCP-1、SDF-1β水平,并根据病毒载量进行亚组分析。结果 AIDS组患者血清中RANTES、MCP-1、SDF-1β水平分别为(1 392.55±227.69)、(450.91±103.04)、(104.82±22.52)pg/mL,均高于健康组[分别为(120.58±55.87)、(74.25±33.62)、(39.04±11.43)pg/mL],差异均具有统计学意义(均P<0.05)。HIV病毒载量4≤Log(VL)<5、Log(VL)≥5的AIDS患者血清中RANTES水平分别为(1 470.34±155.01)、(1 408.29±181.54)pg/mL,均高于Log(VL)<4组患者[(1 183.12±174.54)pg/mL];HIV病毒载量4≤Log(VL)<5的AIDS患者血清中MCP-1、SDF-1β水分别为(537.93±89.32)、(149.31±18.05)pg/mL,高于Log(VL)≥5组[分别为(410.26±80.57)、(81.53±20.31)pg/mL]和Log(VL)<4组患者[分别为(381.71±77.26)、(72.90±21.62)pg/mL],差异均有统计学意义(均P<0.05)。结论 AIDS患者血清RANTES、MCP-1、SDF-1β水平显著升高,且与病毒载量水平有一定的关系。

Objective To evaluate the differences of serum RANTES（regulated on activation, normal T cell expressed and secreted）, MCP-1 （monocyte chemoattractant protein）, and SDF-1β （stromal cell-derived factor-1β） in patients with acquired immunodeficiency syndrome （AIDS） and healthy people.Methods 38 AIDS patients who were admitted to a hospital between January 2010 and January 2015 were as AIDS groups, 38 healthy persons were as a healthy group, serum levels of RANTES, MCP-1, and SDF-1β in two groups were detected, and the subgroup analysis was carried out according to the viral load.Results Serum levels of RANTES, MCP-1, and SDF-1β in AIDS group were （1 392.55±227.69）pg/mL,（450.91±103.04）pg/mL, and（104.82±22.52）pg/mL respectively,all were significantly higher than those in healthy group（[120.58±55.87] pg/mL, [74.25±33.62] pg/mL, and [39.04±11.43]pg/mL respectively）（all P〈0.05）.Among AIDS patients with HIV viral load 4≤Log（VL）〈5 and Log（VL）≥5, serum RANTES were （1 470.34±155.01）pg/mL and （1 408.29±181.54）pg/mL respectively,which were both significantly higher than patients with HIV viral load Log（VL）〈4（[1 183.12±174.54]pg/mL）;serum MCP-1 and SDF-1β levels in AIDS patients with HIV viral load 4≤Log （VL）〈5 were （537.93±89.32）and（149.31±18.05）pg/mL respectively,which were significantly higher than patients with HIV viral load Log（VL）≥5（[410.26±80.57] pg/mL, [81.53±20.31]pg/mL respectively） and HIV viral load Log（VL）〈4（[381.71±77.26] pg/mL, [72.90±21.62]pg/mL respectively）, differences were both statistically significant（both P〈0.05）.Conclusion Serum levels of RANTES, MCP-1, and SDF-1β are significantly increased in AIDS patients, which are related to the level of viral load.