一起宰杀流浪羊所致布鲁菌感染暴发的报告

Report of an outbreak of Brucella infection caused by butchering stray sheep

目的了解布鲁菌感染暴发的流行病学及临床特征,为布鲁菌病的及时诊治和防控提供依据。方法回顾性分析某院2015年12月—2016年4月期间收治的8例布鲁菌病患者的流行病学史、临床症状体征、辅助检查、治疗疗效指标。结果 8例患者均接触了同一只流浪羊并参与宰杀;患者均为男性,平均年龄50岁;均有多汗、乏力等症状,7例出现发热,6例出现腰痛,3例出现四肢肌肉酸痛,2例有咳嗽。8例患者血液中均培养出布鲁菌,特异性抗体滴度1∶200到1∶1 600不等。经利福平联合左氧氟沙星治疗,疗程6周后均康复,观察6个月后未再复发。结论布鲁菌病临床表现不典型,需仔细询问流行病学史,结合病原学加以早诊断、早治疗。

Objective To understand the epidemiological and clinical features of Brucella infection outbreak, provide basis for the timely diagnosis, prevention and control of brucellosis.Methods Epidemiological history, clinical symptoms and signs, auxiliary examination, and therapeutic efficacy of 8 patients with brucellosis and admitted to a hospital between December 2015 and April 2016 were analyzed retrospectively.Results All 8 patients had touched stray sheep and participated in the butchering, all were male patients, with the average age of 50 years;all patients had sweating, fatigue and other symptoms, 7 had a fever, 6 were with lumbago, 3 with muscular soreness, and 2 had a cough.Brucella was cultivated from blood specimens of 8 patients, the specific antibody titers ranged from 1：200 to 1：1 600.All patients recovered from illness through 6-week treatment with rifampin plus levofloxacin, without recurrence after 6-month observation.Conclusion Clinical manifestations of brucellosis are atypical, history of epidemiology should be carefully inquired, combined with etiology, early diagnosis and early treatment can be performed.