中西医结合治疗方案治疗胃食管反流病54例临床研究

Clinical Study on 54 Cases of Gastroesophageal Reflux Disease Treated by Combination of TCM and Western Medicine

目的探讨中西医结合治疗方案治疗胃食管反流病(GERD)的疗效。方法采用中药降逆消瘅汤联合西药奥美拉唑、莫沙必利治疗肝胃郁热型GERD患者54例,疗程8周,治疗前后进行胃食管反流病问卷(GerdQ)、生活质量和肝胃郁热证评分。结果治疗后,中西医联合组总有效率为96.0%,优于对照组(P<0.05)。与对照组相比,中西医联合组治疗后GerdQ和肝胃郁热评分明显降低(P<0.05),且SF-36量表生理机能、身体疼痛、总体健康、精神健康及情感职能等8个维度评分均高于对照组(P<0.05)。结论中西医联合治疗肝胃郁热型GERD疗效确切,优于纯西医治疗。

Objective To explore the curative effect of integrated traditional Chinese and western medicine on gastroesophageal reflux disease（GERD）. Methods The 54 patients were treated with Jiangni-Xiaodan Decoction combined with omeprazole magnesium enteric-coated tablets and Mosapride citrate tablets. The course of treatment was 8 weeks.（Gerd Q）, quality of life and liver-qi stagnation-heat syndrome score before and after treatment. Results Combination of traditional Chinese and Western medicine group the total effective rate was 96%, better than the control group（P 〈 0.05）; group Gerd Q score after treatment and heat stagnation of liver and stomach was lower than the control group（P 〈 0.05）; The treatment group were higher than the control group after treatment of SF-36 scale physiological function, physiological function, body pain, general health, vitality, mental health, social function and emotional function scores of 8 combined traditional Chinese and Western Medicine（P 〈 0.05）. Conclusion The treatment of combination of traditional Chinese and western medicine to GERD with liver and stomach heat syndrome is effective, was better than Western medicine alone.