子痫患者血清TC、TG、LDL-C和HDL-C水平的变化及临床研究

Clinical Significance of TC,TG,LDL-C and HDL-C Changes in Pregnant Women with Preeclampsia

目的:探讨子痫前期(PE)患者血清甘油三酯(triglycerides,TG)、总胆固醇(cholesterol,TC)、低密度脂蛋白胆固醇(lowdensity lipoprotein cholesterol,LDL-C)以及高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)的变化及其临床意义。方法:选取2012年4月至2016年4月我院产科收治的子痫前期患者72例,根据疾病的轻重程度,将其分为轻度子痫前期组(MPE组)(n=38)、重度子痫前期组(SPE组)(n=34)。同时,选取同期的65例正常妊娠者作为对照组。另外选择我院2015年6月至2016年5月诊断的重度子痫前期患者147例,随机分为硝苯地平组(n=72)与拉贝洛尔组(n=75),观察2组患者治疗前后血清TC、TG、LDL-C和HDL-C水平的变化。采用生化法定量检测患者血清TC、TG、LDL-C和HDL-C水平含量。结果:与正常妊娠对照组比较,轻重度子痫前期组血清TC、TG、LDL-C含量明显增加,差异具有统计学意义(P<0.05)。子痫前期组血清HDL-C含量较正常对照组明显减少,差异具有统计学意义(P<0.05)。研究显示,与正常对照组相比,轻度子痫前期组血清TC、TG、LDL-C水平明显增加,差异存在统计学意义(P<0.05)。同时,轻度子痫前期组血清HDL-C水平较对照组显著减少,差异存在统计学意义(P<0.05)。与轻度子痫前期组比较,重度子痫前期组孕妇血清TC、TG、LDL-C水平均明显升高,差异具有统计学意义。同时,重度子痫前期组孕妇血清HDL-C水平较MPE组显著减少,差异存在统计学意义(P<0.05)。结果还显示,口服硝苯地平和静脉注射拉贝洛尔后,重度子痫前期患者血清TC、TG、LDL-C水平均显著减弱,HDL-C水平显著升高(P<0.05)。结论:子痫前期患者血清中TC、TG、LDL-C含量的增加,HDL-C水平的降低与子痫前期的发生发展密切相关,且它们水平的高低与子痫前期的严重程度具有一定相关性,硝苯地平和拉贝洛尔均可以有效控制妊娠期重度子痫前期患者的TC、TG、LDL-C和HDL-C水平。

Objective： To explore the serum levels of TC, TG, LDL-C and HDL-C in the pregnancy women with preeclampsia （PE）, and their clinician value. Methods：From April 2012 to April 2016, 72 cases of PE women were selected, which were divided into mild preeclampsia （MPE） （n=38）, severe preeclampsia （SPE） （n=34）. In addition, 65 cases of normal pregnant woman were selected as the control group. The levels of serum triglycerides （TG）, total cholesterol （TC）, low-density lipoprotein （LDL-C） and high-density lipoprotein cholesterol （HDL-C） were detected by biochemical quantitative method. We also selected 147 cases of severe preeclampsia women from June 2015 to May 2016, which were randomly divided into labetalol treated group （n=75） and nifedipine administrated group （n=72）. Then we detected the levels of TC, TG, LDL-C and HDL-C in severe preeclampsia women before and after treatment. Results：The serum levels of TC, TG, LDL-C in PE pregnant woman were obviously higher than the normal group whereas the serum levels of HDL-C in PE pregnant woman were obviously lower than the normal group. In addition, we also found that the serum TC, TG, LDL-C levels in mild preeclampsia woman were markedly increased but HDL-C level was decreased when compared with normal group. Furthermore, the serum TC, TG, LDL-C levels in severe preeclampsia woman were markedly increased but HDL-C level was decreased when compared with mild preeclampsia woman. Our results also showed that labetalol treatment and nifedipine administration significantly attenuated the increases in serum levels of TC, TG, LDL-C and the decrease in serum HDL-C level in severe preeclampsia woman. Conclusion：The increased content of serum TC, TG, LDL-C as well as the reduced level of serum HDL-C are closely related to the development of preeclampsia, which still reflect the severity of preeclampsia in a way and labetalol as well as nifedipine can effectively control the levels of TC, TG, LDL-C and HDL-C in severe preeclampsia patients.