血清癌胚抗原升高与呼吸系统重症疾病间的关系

The relationship between the rise of serum carcinoembryonic antigen and severe respiratory system diseases

目的探讨危重症患者胚抗原(CEA)升高的原因。方法选择内科ICU(MICU)有CEA升高的214例患者,按有无肿瘤病史分为肿瘤组和非肿瘤组,分析比较两组临床资料。结果肿瘤组中位CEA值明显高于非肿瘤组(P<0.05)。肿瘤组男性患者中位CEA值低于女性患者(P=0.017)。重症感染合并脏器功能衰竭是导致ICU内患者CEA升高的主要原因(占83.18%)。结论 CEA不仅是一项很好的肿瘤标记物,而且可以在一定程度上反应危重症感染患者病情的严重程度。

Objective To investigate the causes of high levels of carcinoembryonic antigen （CEA） in critically ill patients. Methods We retrospectively analyzed 214 patients with elevated CEA levels in Medical Intensive Care Unit （MICU）. These patients were divided into two groups according to whether they had cancer or not. The clinical data were compared between the two groups. Re- suits The CEA levels were increased significantly in the tumor group when compared to non-tumor group （P 〈 0. 05）. The median of the CEA levels in males of the tumor group was significantly higher than that in females （P = 0. 017 ）. Severe infection and organ fail- ure were the main causes of the increase of CEA in critical ill patients （ accounted for 83.18% ）. Conclusion CEA is not only a good tumor marker, but also a good marker of severity of disease in critically ill patients to a certain extent.