腹腔镜手术治疗宫颈癌临床预后的影响因素分析

Risk factors associated with clinical prognosis of cervical cancer treated with laparoscopic surgery

目的分析影响腹腔镜手术治疗宫颈癌临床预后的危险因素。方法研究纳入2013年3月-2016年1月在该院行腹腔镜手术治疗宫颈癌患者80例为研究对象,术后对患者进行随访,并以宫颈癌复发和死亡为终点事件,分析患者总生存期和无病生存期,通过Cox回归模型分析影响宫颈癌手术预后的危险因素。结果 80例患者随访时间12~46个月,中位随访时间39个月。随访期间16例患者复发,6例患者死亡。无病生存期为(41.85±1.06)个月,总生存期为(44.86±0.74)个月。Cox回归分析显示肿瘤大小、临床分期、淋巴结转移和脉管浸润是影响宫颈癌手术预后的独立危险因素。结论影响腹腔镜手术治疗宫颈癌临床预后的独立危险因素为肿瘤大小、临床分期、淋巴结转移和脉管浸润。

Objective To investigate the risk factors associated with clinical prognosis of cervical cancer treated with laparoscopic surgery. Methods 80 patients with cervical cancer were recruited in the study, who underwent radical surgery with laparoscopic surgery from March 2013 to December 2016. The patients were followed up after surgery, and the overall survival and disease free survival was analyzed with tumor recurrence and death as the terminal events. And the risk factors associated with clinical prognosis were identified by using Cox regression analysis. Results The patients were followed up from 12 months to 46 months, and the median period was 39 months. There were 16 recurrences and 6 deaths during the period of follow-up, yielding a disease-free survival of （41.85 ± 1.06） year and an overall survival of （44.86 ± 0.74） year. Cox regression analysis demonstrated that tumor size, clinical stage, lymph node metastasis and vascular invasion were independent risk factors associated with clinical prognosis of cervical cancer treated with laparoscopic surgery. Conclusion Tumor size, clinical stage, lymph node metastasis and vascular invasion were independent risk factors associated with clinical prognosis of cervical cancer treated with laparoscopic surgery.