高龄前列腺癌患者外周血循环肿瘤细胞与临床特征的相关性研究

Study on Correlation Between the Level of Circulating Tumor Cells in Peripheral Blood and Clinical Characteristics in Aged Patients with Tumor

目的 通过检测老年前列腺癌患者外周血循环肿瘤细胞（circulating tumor cells,CTCs）数目,探讨CTCs在前列腺癌患者病情评估中的价值.方法 收集前列腺癌患者及对照组人员.记录其CTCs数目、年龄、血常规、血凝常规、生化常规、前列腺癌特异抗原（PSA）、前列腺磁共振、骨扫描等结果.分析CTCs数目与上述指标的相关性.结果 1.患者CTCs数与肿瘤发病及转移有相关性.2.患者CTCs数与血清PSA有相关性.3.患者CTCs数与血红蛋白（HB）、碱性磷酸酶（AKP）、血小板（PLT）、纤维蛋白原（FIB）、D-二聚体（D-D）水平有相关性.结论 前列腺癌患者CTCs水平与肿瘤发生、肿瘤转移、相关血清指标有相关性,可以与相关检查结果联合预测患者疾病进展情况.

Objective To analyze the meaning of circulating tumor cells （CTCs） monitoring in early diagnosis of prostate cancer and early detection of metastasis, through the detection of CTCs in peripheral blood of elderly patients with prostate cancer. Methods Cases of prostate cancer and control group were collected from patients, to record their age, blood routine, blood clotting routine, biochemical routine, prostate cancer specific antigen （PSA）, MR, bone scan and other imaging results. SPSS 22.0 software package was used to analyze the correlation between the number of CTCs and the above indexes. Results 1.The level of CTCs in prostate cancer patients had no relevance with age, but was associated with tumor metastasis. 2.The level of CTCs in prostate cancer patients was associated with the level of PSA. 3.The level of CTCs in prostate cancer patients was associated with the levels of HB, PLT, FIB, D-D and AKP. Conclusion The level of CTCs in aged patients is associated with tumor metastasis, and has relevance with the levels of HB, PLT, FIB, D-D and AKP, which can be used as evaluation index, and can predict a patient＆#39;s risk of disease progression.