复方甘草酸苷联合西咪替丁对过敏性紫癜患儿体征改善及血清T细胞亚群、IL-1β水平变化的影响

Effects of Compound Glycyrrhizin Combined with Cimetidine on Signs Improvement, Serum T Cell Subsets and IL-1β Levels in Children with Henoch-Sch？nlein Purpura

目的 探讨复方甘草酸苷联合西咪替丁对过敏性紫癜患儿体征改善及血清T细胞亚群、白细胞介素-1β（IL-1β）水平变化的影响.方法 选取2014年4月—2016年8月74例过敏性紫癜患儿,随机数字表法分为2组,各37例.对照组采用西咪替丁,研究组采用西咪替丁＋复方甘草酸苷,两组均持续治疗2周.疗程结束后统计对比两组体征改善情况、临床疗效、治疗前后T细胞亚群指标及IL-1β水平.结果 研究组水肿消失、关节肿痛消失、皮肤紫癜消失用时较对照组少,差异有统计学意义（P〈0.05）;两组总有效率比较,研究组94.59％（35/37）较对照组72.97％（27/37）高,差异有统计学意义（P〈0.05）;治疗后研究组CD3＋、CD4＋、CD4＋/CD8＋水平较对照组高,CD8＋、IL-1β水平较对照组低,差异有统计学意义（P〈0.05）.结论 西咪替丁联合复方甘草酸苷治疗过敏性紫癜可有效缓解患儿临床体征,降低血清IL-1β水平,增强其机体免疫功能.

Objective To investigate the effect of compound glycyrrhizin combined with cimetidine on signs improvement and serum T cell subsets and interleukin-1β （IL-1β） levels in children with Henoch-Sch？nlein purpura. Methods From April 2014 to August 2016, 74 children with Henoch-Sch？nlein purpura in our hospital were randomly divided into control group and study group, each group 37 cases. The control group was treated with cimetidine, the study group using cimetidine ＋ compound glycyrrhizin, and the two groups were treated for 2 weeks. Signs of improvement, clinical efficacy, T cell subsets before and after treatment and IL-1β levels were statistically compared between the two groups after the course of treatment. Results The edema disappeared, joint swelling and pain disappeared, skin purpura disappeared time in the study group were significantly less than that of the control group （P〈0.05）; The total effective rate of the study group 94.59% （35/37） was higher than that of the control group 72.97% （27/37）, the difference was statistically significant （P〈0.05）; The levels of CD3＋, CD4＋, CD4＋/CD8＋ in the study group were significantly higher than those in the control group, and the levels of CD8＋and IL-1β were significantly lower than those in the control group （P〈0.05）. Conclusion Cimetidine combined with compound glycyrrhizin in the treatment of allergic purpura can effectively relieve the clinical signs, reduce the serum IL-1βlevel and enhance the immune function of the body.