原发性肝癌的实验室诊断

Laboratory diagnosis of primary hepatocellular carcinoma

原发性肝癌是指原发于肝脏的上皮源性恶性肿瘤,主要包括肝细胞癌和肝内胆管细胞癌。实验室检查是原发性肝癌诊断的重要手段,其中临床病理学检查是原发性肝癌诊断的"金标准"。随着精准医学概念的提出和个体化治疗的迅猛发展,实验室检查在原发性肝癌早期诊断、靶向分子鉴定、肿瘤监测和预后评估等方面承担了更多的责任。本文对原发性肝癌的实验室诊断作一综述。

Primary hepatocellular carcinoma （PHC） refers to primary liver malignant epithelial tumors, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Laboratory tests are the important means for PHC diagnosis, especially the clinical pathological examination is considered as gold standard. Following the acceptation of precision medicine by more and more people and currently rapid development of individualized treatment, laboratory tests are paid to more responsibilities for the early diagnosis, target molecular identification, tumor detection and prognosis assessment of PHC. This review focuses on the role of laboratory tests in PHC diagnosis.