喹唑啉类衍生物的合成及生物活性研究进展

Research Progress on Synthesis and Biological Activity of Quinazoline Derivatives

在近些年发展中的农药进程中,由于喹唑啉类化合物的广谱生物活性和多变的结构类型,因此引起了广大人们的关注,也显示出了其广泛的应用和发展前景,目前喹唑啉类化合物已有部分成功开发为商品药物,如氟喹唑(杀菌剂)、喹螨醚(杀螨剂)和易瑞沙(抗癌药物)等。本文综述了近年来喹唑啉(酮)类化合物农用生物活性和医用生物活性的研究进展。

In the development of pesticides in recent years, quinazoline （ketone） compounds have attracted much attention because of their broad- spectrum biological activity and changeable structure, many compounds containing quinoline ring structure show a wide application and development prospects, quinazoline compounds have been successfully developed for commercial drugs currently, such as fluorine quinazoline （fungicide） , fenazaquin （acaricides） and iressa （anticancer drug）. The research progress on the biological activities and biological activities of quinazoline （keto） compounds in agriculture were reviewed.