SigmaPlot在拟合纳米载体蛋白药物的体外释放中的应用

SigmaPlot Determine Water-soluble Chitosan Nanoparticle Carrier Protein Drug Release in Vitro Model

采用SigmaPlot软件探讨水溶性壳聚糖(WSC)纳米蛋白药物载体的体外释放规律。以牛血清蛋白(BSA)为模型药物,分别采用动力学模型、Weibull模型、Gompertz模型、Logistic模型、Higuchi模型对纳米粒子的蛋白释放,进行拟合试验。供试7个模型中,除Higuchi和Logistic模型外,其余模型均能较好地拟合BSA的释放情况。因此SigmaPlot作出的Gompertz二级模型能很好地拟合WSC纳米载体体系BSA的释放规律。

Using SigmaPlot software to study the water soluble chitosan （WSC） in vitro release regularity of nano drug carrier protein, Bbovine serum albumin （BSA） as the model drug, dynamics model and Weibull model were used respectively to Gompertz model, Logistic model, the Higuchi model protein release of nanoparticles, fitting of experiment was carried out. In the selected seven models, besides Higuehi and Logistic model, other models can be better fitting of the BSA release. Gompertz model 2 to SigmaPlot was well fitting system of WSC nanometer carrier BSA release regularity and the model parameters with the actual physical meaning.