地特胰岛素联合格列齐特缓释片治疗2型糖尿病观察

Observation of Insulin Detemir Combined with Gliclazide Sustained-release Tablets for the Treatment of Type 2 Diabetes

目的研究地特胰岛素联合格列齐特缓释片治疗2型糖尿病的临床疗效及对肝肾功能的影响。方法选择该院2013年3月—2015年8月肾癌患者的临床病例100例进行分析,随机分为观察组和对照组,每组50例。对照组采取常规的治疗,观察组采取地特胰岛素联合格列齐特缓释片口服方式治疗,观察比较两组患者的肝肾功能、治疗期间出血低血糖例数和C肽在餐前餐后波动检测值等。结果两组患者的肝肾功能没有明显的变化,差异无统计学意义(P>0.05);观察组治疗期间出现低血糖的例数明显低于对照组,差异有统计学意义(P<0.05);C肽检测结果上在治疗前两组组间对比,差异无统计学意义(P>0.05);治疗后两组都有大幅度上升,观察组上升幅度比对照组大(P<0.05)。结论地特胰岛素联合格列齐特缓释片治疗可以更好的控制2型糖尿病的病情,治疗安全性高,值得在临床上广泛使用。

Objective This paper tries to study the clinical effect of insulin detemir combined with gliclazide sustained- release Tablets for the treatment of type 2 diabetes and its impact on kidney function. Methods 100 cases of renal cell carcinoma from March 2013 to August 2015 in this hospital were analyzed and randomly divided into the observation group and the control group, with 50 cases in each group. The control group received routine treatment, the observation group was received insulin detemir combined with gliclazide sustained-release tablets oral treatment, and then the liver and kidney function, hemorrhage cases of hypoglycemia and C peptide fluctuation detection value before and after meals of the two groups were observed and compared. Results The liver and kidney function of two groups did not change obviously, the difference was not statistically significant（P〉0.05）; the number of cases of hypoglycemia in the observation group was significantly lower than the control group during the treatment, the difference was statistically significant（P〈0.05）; C peptide test results before and after meals of the two groups were compared, the difference was not statistically significant（P〉0,05）; but the value increased in the two groups after treatment, and the observation group increased significantly more than the control group（P〈0.05）. Conclusion Insulin detemir combined with gliclazide sustained-release tablets for the treatment of type 2 diabetes can better control the disease with high safety, so it is worth clinical application：