地屈孕酮治疗痛经的临床效果观察

Clinical effect of dydrogestrone in treatment of dysmenorrhea

目的:评价地屈孕酮治疗痛经的疗效。方法:选取2013年8月至2014年3月间在上海市同济大学附属第一妇婴保健院经治的41例痛经患者作为研究对象。轻、中度痛经患者从月经周期第11~25 d,每日2次,每次口服地屈孕酮10 mg;重度痛经患者从月经周期第5~25 d,每日2次,每次口服地屈孕酮10 mg。两组均治疗3个持续月经周期。治疗前至随访终点使用视觉模拟评分法(the visual analogue scale,VAS)评分方法对患者进行疼痛评分,同时记录患者行经天数、经量、镇痛药使用情况及不良反应。结果:所有至随访终点患者痛经症状均明显改善,VAS评分显著下降,行经天数稳定,经量适中,服用止痛药物剂量降低,2例出现轻微不良反应,数天后症状自行消失。结论:地屈孕酮治疗痛经安全有效。

Objective： To evaluate clinical effects and advantages of dydrogestrone in the treatment of dysmenorrhea. Methods： This study was performed in 41 women diagnosed as dysmenorrhea who underwent treatment with dydrogestrone in our hospital from August 2013 to March 2014. The degree of dysmenorrheal was assessed according to visual analogue scale （VAS）. Patients with mild to moderate dysmenorrheal took dydrogesterone 10mg twice a day from Day 11 to Day 25 of menstrual cycle. At the same time, patients with severe dysmenorrheal took dydrogesterone 10mg twice a day from Day 5 to Day 25 of menstrual cycle. Both groups were treated for three continuous menstrual cycles. Data were collected by the VAS from 1 month before treatment until 1 month after treatment. The menstruation length, the menstrual volume, the use of analgesic and adverse effects were also recorded. Results： The results showed that the score of VAS 1 months after treatment was significantly lower than before. The symptoms of dysmenorrhea were significantly improved, the menstruation days remain stable, the volume is moderate and the total number of painkiller used decreased. Conclusion： VAS score was significantly lower after three courses of dydrogestrone treatment in patients. Dydrogesterone can be considered as an effective and safe option for the treatment of dysmenorrheal.