罗西维林、艾瑞昔布联合舒适护理防治经尿道前列腺激光切除术后胱痉挛的疗效观察

Efficacy of rociverine tablets combined with imrecoxib tablets and comfortable nursing in the control of bladder spasm after transurethral laser resection of prostate

目的 探讨罗西维林、艾瑞昔布联合舒适护理防治经尿道前列腺激光切除（TULRP）术后膀胱痉挛的疗效.方法 将住院接受TULRP术的120例前列腺增生（BPH）患者按随机数字表法分为四组,每组30例.联合用药组（A组）：罗西维林片10 mg,口服,3次/d;艾瑞昔布片100 mg,口服,2次/d,至拔管当日;罗西维林组（B组）：罗西维林片10 mg,口服,3次/d,至拔管当日;艾瑞昔布组（C组）：艾瑞昔布片100 mg,口服,2次/d,至拔管当日;对照组（D组）：疼痛时予吲哚美辛栓50 mg塞肛;所有患者均给予舒适护理.观察比较72 h内各组患者膀胱痉挛次数、膀胱痉挛平均持续时间、膀胱冲洗时间和冲洗液转清时间.结果 A、B、C三组膀胱痉挛次数、膀胱痉挛平均持续时间、膀胱冲洗时间和冲洗液转清时间均明显少于D组,差异均有统计学意义（Fa=9.469、Fb=13.443、Fc=12.157、Fd=26.609、Fe=33.717、Ff=30.524、Fg=100.836、Fh=89.985,均P3＜0.001）.A组与B组比较,差异均有统计学意义（P1=0.030、0.002、0.012、0.003、＜0.001、＜0.001、＜0.001、＜0.001）;A组与C组比较,差异均有统计学意义（P2=0.030、0.004、0.035、0.001、＜0.001、＜0.001、＜0.001、＜0.001）.B组与C组之间比较,差异均无统计学意义（均P4 ＞0.05）.结论 预防性使用罗西维林和艾瑞昔布,并予以舒适护理,能够有效防治经尿道前列腺激光切除术后膀胱痉挛,安全性高,值得临床推广应用.

Objective To assess the efficacy of rociverine tablets combined with imrecoxib tablets and comfortable nursing in the control of bladder spasm after transurethral laser resection of prostate.Methods According to the digital table,120 patients who diagnosed as benign prostate hyperplasia （BPH） were randomly divided into four groups.The patients in combined drug group （group A） were administered rociverine tablets（10mg tid） and imrecoxib tablets （100mg bid） from the day of surgery to the day of catheter removal.The patients in rociverine tablets group （group B） were treated with rociverine tablets （10rag tid）,and the patients in imrecoxib tablets group （group C） were administered imrecoxib （100mg bid） from the day of surgery to the day of catheter removal.The patients in group D were administered indometacin suppositories in anus when they felt pain.All patients were given comfortable nursing.The frequency and duration of bladder spasm,the time of bladder irrigation,time needed for washing solution to turn clear,and the time of catheter indwelling in the four groups were observed and compared.Results Compared with group D,group A,group B and group C all had statistically significant differences in the frequency and duration of bladder spasm,the time of bladder irrigation,time needed for washing solution to turn clear,and the time of catheter indwelling （Fa =9.469,Fb =13.443,Fo =12.157,Fd =26.609,Fe =33.717,Ff =30.524,Fs =100.836,Fh =89.985,P3 〈 0.001）.These parameters were lower in group A than those in group B and group C,and the differences were statistically significant （P1 =0.030,0.002,0.012,0.003,〈 0.001,〈 0.001,〈 0.001,〈 0.001;P2 =0.030,0.004,0.035,0.001,〈 0.001,〈 0.001,〈 0.001,〈 0.001）.There were no statistically significant differences between group B and group C （all P4 〉 0.05）.Conclusion Rociverine tablets combinined with imrecoxib tablets for the prevention and treatment of bladder spasm after transurethral laser resection of prostate was effective,which was worthy of clinic application.