不同剂量盐酸坦洛新缓释片用于Ⅲ型前列腺炎的疗效比较

Comparison of treatment effects of different dosage of tamsulosin for patients with type Ⅲ prostatitis

目的 探讨不同剂量盐酸坦洛新缓释片治疗Ⅲ型前列腺炎的临床疗效及安全性.方法 选取Ⅲ型前列腺炎患者150例为研究对象,采用随机数字表法分为观察组75例、对照组75例,观察组患者给予盐酸坦洛新缓释片2片（0.4 mg）治疗,1次/d;对照组给予盐酸坦洛新缓释片1片（0.2 mg）＋淀粉片1片治疗,1次/d.治疗12周后比较两组临床疗效、美国国立卫生研究院慢性前列腺炎症状评分（NIH-CPSI）改善情况、白细胞计数及pH值改善情况、不良反应发生情况.结果 观察组总有效率高于对照组（93.33％比81.33％）,差异有统计学意义（χ2=4.881,P＜0.05）.治疗后观察组疼痛、排尿症状、生活质量及NIH-CPSI总分分别为（5.13±4.02）分、（2.52±1.07）分、（3.64±3.25）分、（9.19±0.63）分,均低于对照组的（8.25±3.54）分、（3.28±1.87）分、（5.57±3.62）分、（16.47±0.38）分,两组差异均有统计学意义（t=5.044、3.055、3.436、85.693,均P＜0.05）.治疗后观察组白细胞计数、pH值分别为（12.65±5.88）×109/L、（6.29±0.20）,均低于对照组低的（16.58±6.24）×109/L、（6.73±0.16）,两组差异均有统计学意义（t=3.970、14.878,均P＜0.05）.两组不良反应单项发生率及总发生率差异均无统计学意义（χ2=0.340、0.207、0.000、0.000、0.362,均P＞0.05）.结论 应用0.4 mg盐酸坦洛新缓释片治疗Ⅲ型前列腺炎的临床疗效优于0.2 mg,且对安全性无明显影响.

Objective To compare the treatment effects of different dosage of tamsulosin for patients with type Ⅲ prostatitis.Methods 150 patients with type Ⅲ prostatitis were selected as study objects.They were divided into control group and research group according to the digital table,each group in 75cases.The research group was treated with tamsulosin 2 tablets （0.4mg）,1 time a day.The control group was treated with tamsulosin 1 tablet （0.2mg） ＋ starch tablet 1 tablet,1 time a day.After treatment for 12 weeks,the clinical effects,NIH-CPSI score,white blood cell count and pH value,and adverse reaction between the two groups were compared.Results The total effective rate of the research group was higher than that of the control group（93.33% vs.81.33%）,the difference was statistically significant （χ2 =4.881,P 〈 0.05）.After treatment,the pain,voiding symptoms,quality of life and NIH-CPSI scores in the research group were （5.13 ± 4.02） points,（2.52 ± 1.07） points,（3.64 ± 3.25） points,（9.19 ± 0.63） points,respectively,which were lower than those in the control group [（8.25 ± 3.54） points,（3.28 ± 1.87） points,（5.57 ± 3.62） points,（16.47 ± 0.38） points],the differences were statistically significant （t =5.044,3.055,3.436,85.693,all P 〈0.05）.The white blood cell and pH value of the research group were （12.65 ± 5.88） × 109/L,（6.29 ±0.20）,respectively,which were lower than those in the control group [（16.58 ±6.24） × 109/L,（6.73 ± 0.16）],the differences were statistically significant （t =3.970,14.878,all P 〈 0.05）.The single occurrence rate and total occurrence rate between the two groups had no statistically significant differences （χ2 =0.340,0.207,0.000,0.000,0.362,all P 〉 0.05）.Conclusion The effect of tamsulosin in dose of 0.4 mg is better than 0.2 mg,and had no significant impact on safety.