强直性脊柱炎名医医案用药规律研究

Research of the medication rules of ankylosing spondylitis based on the famous doctors＆#39; medical records

目的 基于＂中医医案知识服务与共享系统（V1.2.8）＂,挖掘强直性脊柱炎名医医案的用药规律.方法 搜集＂中医医案知识服务与共享系统（V1.2.8）＂中收录的有关强直性脊柱炎的名医医案,构建数据库并应用软件中的频次分析、关联分析、药对分析、核心药物聚类分析等方法进行数据挖掘,分析名医医案用药规律.结果 共收集医案100篇,合计149首处方,包含210味药物,其中使用频次较高的药物包括狗脊、白芍、当归、杜仲、威灵仙等,出现频次在20次以上的中药多以补益肝肾、活血化瘀、清热利湿、散寒除湿药为主;使用频次较高的药物组合包括＂桑寄生、狗脊＂＂杜仲、狗脊＂＂白芍、狗脊＂＂桂枝、白芍＂＂甘草、当归＂等.结论 中药治疗强直性脊柱炎以补益肝肾的药物为主,辅以温补肾阳、散寒除湿、活血化瘀、清热利湿、祛风散寒等药物,从而达到标本兼治的目的.

Objective Applyingthe traditional Chinese medical knowledge service and sharing system, to explore the medication rules of ankylosing spondylitis in the medical records.Methods The ankylosing spondylitis medical records in the traditional chinese medical knowledge service and sharing system has been searched and 149 prescriptions were identified. The medication frequency, association rules, herbal combination and the cluster analyses were explored.Results Among the 149 prescriptions with 210 drugs, the use of high frequency drugs wereGouji, Baishao, Danggui, Duzhong, Weilingxian, and other medication whose frequency was more than 20 times were good at tonifying liver and kidney, activating blood circulation, clearing heat and promoting diuresis, dispelling cold and removing dampness. The high frequency of drug combinations included ＆quot;Sangjisheng and Gouji＆quot;, ＆quot;Duzhong and Gouji＆quot;, ＆quot;Baishao and Gouji＆quot;, ＆quot;Guizhi and Baishao＆quot;, ＆quot;Gancao and Danggui＆quot;.Conclusions The treatment of ankylosing spondylitis with Chinese medicine is mainly based on tonifying liver and kidney, supplemented with drugs for warming Kidney Yang, dispelling cold and dehumidification, promoting blood circulation and removing blood stasis, clearing heat and promoting diuresis, dispelling wind and cold.