顺铂联合替吉奥方案治疗晚期胃癌的疗效及安全性研究

The Efficacy and Safety of Cisplatin Combined With Tiogo in the Treatment of Advanced Gastric

目的研究顺铂联合替吉奥方案治疗晚期胃癌的疗效及安全性。方法选取2012年9月至2015年3月我院肿瘤科收治的54例晚期胃癌患者,根据治疗方式不同分为对照组和治疗组,每组27例,对照组采用顺铂联合氟尿嘧啶化疗方案,治疗组采用顺铂联合替吉奥化疗方案。经过2个周期化疗后,比较两组患者的治疗效果和不良反应发生情况。随访1年,观察两组患者的中位生存期。结果治疗组的临床总有效率和不良反应发生情况均明显优于对照组(P<0.05);治疗组患者的中位生存期明显高于对照组,差异具有统计学意义(P<0.05)。结论顺铂联合替吉奥方案治疗晚期胃癌的疗效确切,能够延长患者中位生存期,安全性高,可作为晚期胃癌患者较理想的辅助治疗方案。

Objective To study the efficacy and safety of cisplatin combined with Tiogo in the treatment of advanced gastric cancer.Methods We selected 54 patients with advanced gastric cancer from September 2012 to March 2015,according to different treatment were divided into control group and treatment group, each group of 27 cases, control group adopt cisplatin chemotherapy regimens,fluorouracil for gonow treatment group with cisplatin plus chemotherapy regimens.After two cycles of chemotherapy, com- pared two groups of patients with the Treatment effect and adverse reactions occur.Follow-up of 1 year,observing the living in term of two groups of patients.Results The clinical total effective rate in treatment group and the adverse reactions happen situation is better than the control group（P〈0.05 ） ; Patients with the living in term of treatment group was significantly higher than that of control group（P〈0.05）,the difference is statistically significant.Conclusion Cisplatin combined with tegio the program for the treatment of advanced gastric cancer with exact efficacy, to extend the survival of patients, high security, can be used as an ideal adjuvant thera- py for patients with advanced gastric cancer.