2Roberts JR, Allison DC, Donehower RC, et al. Develop- ment of polyploidization in taxol-resistant human leukemia cells in vitro[J]. Cancer Res, 1990, 50(3) : 710 -716.
3Bouhon TG, Nye SH, Robbins DJ, et al. Erks: a family of protein-serine threonine kinases that are activated and tyro- sine phosphorylated in response to insulin and NGF [ J ]. Cell, 1991,65(4) : 663 -675.
4Katsuya S, Koujiro T, Takeshi N. The emerging role of caspase inhibitors in gastrointestinal cancer[J~. J Gastro- enterol, 2002,37 (5) :323 - 331.
5Tamm I, Wang Y, Sattsville E, et al. IAP family protein survivin inhibits caspases, and anticancer drugs [ J ]. Canc- er Res, 1998,58 (23) :5315 - 5320.
6Dohi T, Beltrami E, Wall NR, et al. Mitochondrial sur- vivin inhibits apoptosis and promotes tumorigenesis [ J ]. J Clin Invest, 2004,114 (8) : 1117 - 1127.
7Verhagen AM, Ekort PG, Pakusch M, et al. Identification of Diablo, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins [ J ]. Cell, 2000, 102(1) :43 -53.
8Verhagen AM, Vaux DL. Cell death regulation by the mam- malian IAP antagonist Diablo Smac [ J ]. Apoptosis, 2002,7 (2) :163 - 166.
9Mitza A, Mcguirk M, Hockenberry TN, et al. Human sur- vivin is negatively regulated by wild-type p53 and partici- pates in p53-dependent apoptotic pathway [ J ]. Oncogene, 2002,21 ( 17 ) :2613 - 2622.
