血清Irisin水平与非酒精性脂肪性肝病的相关性研究

A study on the correlation between serum Irisin level and non-alcoholic fatty liver disease

[目的]探讨血清鸢尾素(Irisin)水平与不同非酒精性脂肪性肝病(NAFLD)病变程度的相关性。[方法]选取我院2014年11月~2015年12月收治的NAFLD患者140例作为研究对象,根据患者病变严重程度,将患者分为轻度、中度、重度、极重病变程度组。另选取同期我院健康体检者148例作为对照组,收集2组患者的实验室检查资料及一般资料进行分析,探讨Irisin水平与不同NAFLD病变程度的相关性。[结果]观察组患者总胆固醇、甘油三酯、AST、ALT、血清Irisin、收缩压、舒张压、腰围、臀围、空腹血糖、空腹胰岛素、HOM-IR水平明显高于对照组健康体检者,差异有统计学意义(P<0.05);总胆固醇、甘油三酯、血清Irisin、AST、空腹血糖、空腹胰岛素、HOM-IR在4组患者间差异有统计学意义(P<0.05);总胆固醇、高密度脂蛋白与血清Irisin水平呈现明显负相关性(P<0.05);空腹胰岛素、HOM-IR、AST与血清Irisin水平呈现明显正相关性(P<0.05);多元Logistic回归分析显示HOM-IR、AST、空腹胰岛素及血清Irisin水平是影响NAFLD发生的独立危险因素(P<0.001)。[结论]血清Irisin水平是影响NAFLD发生的独立危险因素,随NAFLD病情的进展血清Irisin水平逐渐降低。

[Objective]To investigate the correlation between serum Irisin level and non-alcoholic fatty liver disease（NAFLD）.[Methods]140patients with NAFLD in our hospital from November 2014 to December 2016 were selected as the research object.According to the severity of disease,the patients were divided into mild group,moderate group,severe group and extremely severe group.Another 148 healthy persons in our hospital were selected as the control group.The data of the laboratory examination and the general data of the patients in the two groups were collected and analyzed.The correlation between the serum Irisin level and the severity of the different NAFLD were investigated.[Results]The total cholesterol,triglyceride,AST,ALT,serum Irisin,systolic blood pressure,diastolic blood pressure,waist circumference,hip circumference,fasting blood glucose,fasting insulin and HOM-IR levels in observation group were significantly higher than those in the control group and the differences were statistically significant（P〈0.05）.The total cholesterol,triglyceride,serum Irisin,AST,fasting blood glucose,fasting insulin and HOM-IR were obviously different among the four groups patients（P〈0.05）.There were significant negative correlation between serum Irisin and total cholesterol,high density lipoprotein（P〈0.05）.There were significant positive correlation between and serum Irisin levels and HOM-IR,AST,and fasting insulin（P〈0.05）.Multivariate logistic regression analysis showed that HOM-IR,AST,fasting insulin and serum Irisinlevels were independent risk factors of NAFLD liver disease（P〈0.001）.[Conclusion]The serum Irisin level was an independent risk factor for the occurrence of NAFLD liver disease,and the serum Irisin level decreased with the progression of NAFLD liver disease.